BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER

Base Information

Chemical Name:BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER
CAS No.:894802-87-0
Molecular Formula:C₁₈H₁₈O₃
Molecular Weight:282.339
Hs Code.:
Mol file:894802-87-0.mol

Synonyms:ethyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate

Suppliers and Price of BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER

There total 5 articles about BETA-OXO-1,1'-BIPHENYL-4-BUTANOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2033-24-1
cycl-isopropylidene malonate

: 64-17-5
ethanol

: 39889-69-5
biphenyl-4-yl-acetyl chloride

: 894802-87-0
ethyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate

Guidance literature:: cycl-isopropylidene malonate; biphenyl-4-yl-acetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

ethanol; for 2h; Heating;
DOI:10.1021/ja060729t

Reference yield: 89.9%

: 5728-52-9
(4-biphenylyl)acetic acid

: 6148-64-7
ethyl potassium malonate

: 894802-87-0
ethyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate

Guidance literature:: (4-biphenylyl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 16.25h; Inert atmosphere;

ethyl potassium malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; for 29h; Inert atmosphere;

Reference yield:

: 5728-52-9
(4-biphenylyl)acetic acid

: 894802-87-0
ethyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂ / CH₂Cl₂ / Heating

2.1: DIEA / CH₂Cl₂ / 4 h / 0 - 20 °C

2.2: 97 percent / 2 h / Heating

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja060729t