4-chloro-N-(4-methoxyphenyl)aniline

Base Information

• Chemical Name: 4-chloro-N-(4-methoxyphenyl)aniline
• CAS No.: 41018-73-9
• Molecular Formula: C13H12ClNO
• Molecular Weight: 233.697
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID80517666
• Nikkaji Number: J29.653H
• Wikidata: Q82379808
• Mol file: 41018-73-9.mol

Synonyms:41018-73-9;4-chloro-N-(4-methoxyphenyl)aniline;(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE;N-(4-CHLOROPHENYL)-4-METHOXYANILINE;SCHEMBL9629628;4-Methoxy-phenyl 4-Chloranilin;DTXSID80517666;AKOS015967254;FT-0717566

Chemical Property of 4-chloro-N-(4-methoxyphenyl)aniline

Chemical Property:

• PSA: 21.26000
• LogP: 4.16520
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 233.0607417
• Heavy Atom Count: 16
• Complexity: 196

Purity/Quality:

99% ^*data from raw suppliers

(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC2=CC=C(C=C2)Cl

Technology Process of 4-chloro-N-(4-methoxyphenyl)aniline

There total 19 articles about 4-chloro-N-(4-methoxyphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-bromo-4-methoxy-benzene (104-92-7) + 4-chloro-aniline (106-47-8) → 4-chloro-N-(4-methoxyphenyl)aniline (41018-73-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6.5h;

DOI:10.1039/d1nj03468e

Reference yield: 90.0%

para-iodoanisole (696-62-8) + 4-chloro-aniline (106-47-8) → 4-chloro-N-(4-methoxyphenyl)aniline (41018-73-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

DOI:10.1039/d1nj03468e

Reference yield: 86.0%

4-methoxyphenylboronic acid (5720-07-0) + 4-chlorobenzonitrile (100-00-5) → 4-chloro-N-(4-methoxyphenyl)aniline (41018-73-9)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 30 ℃; for 48h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/acs.orglett.1c03343

upstream raw materials:

1,2-bis(4-methoxyphenyl)-1,2-diphenylhydrazine

1-Chloro-4-iodobenzene

para-iodoanisole

1-bromo-4-methoxy-benzene

Downstream raw materials:

Variamin Blau

ethyl 5-chloro-1-(4-methoxyphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

ethyl 1-(4-chlorophenyl)-5-methoxy-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide

ethyl 2-[N-(4-chlorophenyl)-N-(4-methoxyphenyl)sulfamoyl]-2-diazoacetate