2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE

Base Information

• Chemical Name: 2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE
• CAS No.: 412923-44-5
• Molecular Formula: C9H5BrFNS
• Molecular Weight: 258.114
• Mol file: 412923-44-5.mol

Synonyms:

Chemical Property of 2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE

Chemical Property:

• PSA: 41.13000
• LogP: 3.71170

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-(4-fluorophenyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE

There total 3 articles about 2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(4-fluorophenyl)-2-thiocyanatoethan-1-one (43045-16-5) → 2-bromo-4-(4-fluorophenyl)thiazole (412923-44-5)

Guidance literature:

With hydrogen bromide; In acetic acid; at 130 ℃; for 3h;

DOI:10.1016/j.bmc.2012.11.006

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 2-bromo-4-(4-fluorophenyl)thiazole (412923-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide

2: hydrogen bromide; acetic acid / water

With hydrogen bromide; acetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1021/co1000234

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-bromo-4-(4-fluorophenyl)thiazole (412923-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / 1,4-dioxane; diethyl ether

2: N,N-dimethyl-formamide

3: hydrogen bromide; acetic acid / water

With hydrogen bromide; bromine; acetic acid; In 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1021/co1000234

upstream raw materials:

1-(4-fluorophenyl)ethanone

2-bromo-4'-fluoroacetophenone

1-(4-fluorophenyl)-2-thiocyanatoethan-1-one

Downstream raw materials:

1-(4-(4-fluorophenyl)thiazol-2-yl)-4-phenyl-1H-1,2,3-triazole

tert-butyl 4-[4-(4-fluorophenyl)thiazol-2-yl]piperazine-1-carboxylate

N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(4-fluorophenyl)thiazol-2-yl]-1-carboxamide

4-(4-fluorophenyl)-2-(piperazin-1-yl)thiazole

Refernces

• 1、 Li, Wen-Tai,Wu, Wan-Hsun,Tang, Chien-Hsiang,Tai, Ready,Chen, Shui-Tein. "One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3- triazoles as anticancer agents". . p. 72 - 78. Retrieved 2011/04/17.