1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine

Base Information

Chemical Name:1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine
CAS No.:887625-25-4
Molecular Formula:C13H14FN3S
Molecular Weight:263.339
Hs Code.:
DSSTox Substance ID:DTXSID601259755

Synonyms:1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine;887625-25-4;4-(4-fluorophenyl)-2-piperazin-1-yl-1,3-thiazole;SCHEMBL194798;DTXSID601259755;STK664175;AKOS003392008;BS-33477;1-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine;4-(4-fluorophenyl)-2-piperazino-1,3-thiazole;EN300-14652337;Piperazine, 1-[4-(4-fluorophenyl)-2-thiazolyl]-;4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine;1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl] piperazine

Suppliers and Price of 1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:263.08924679
Heavy Atom Count:18
Complexity:265

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC(=CS2)C3=CC=C(C=C3)F

Technology Process of 1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine

There total 3 articles about 1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 887625-25-4
4-(4-fluorophenyl)-2-(piperazin-1-yl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / 80 °C

2: hydrogen bromide / acetic acid / 3 h / 130 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C

4: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; water; hydrogen bromide; potassium carbonate; In ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.006

Reference yield:

: 412923-44-5
2-bromo-4-(4-fluorophenyl)thiazole

: 887625-25-4
4-(4-fluorophenyl)-2-(piperazin-1-yl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C

2: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; water; potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.006

Reference yield:

: 43045-16-5
1-(4-fluorophenyl)-2-thiocyanatoethan-1-one

: 887625-25-4
4-(4-fluorophenyl)-2-(piperazin-1-yl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / acetic acid / 3 h / 130 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C

3: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; water; hydrogen bromide; potassium carbonate; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.006