Benzo[D]Thiazol-2-Yl(4-Methoxyphenyl)Methanol

Base Information

• Chemical Name: Benzo[D]Thiazol-2-Yl(4-Methoxyphenyl)Methanol
• CAS No.: 413606-87-8
• Molecular Formula: C15H13NO2S
• Molecular Weight: 271.33400
• Hs Code.: 2934200090
• Mol file: 413606-87-8.mol

Synonyms:

Chemical Property of Benzo[D]Thiazol-2-Yl(4-Methoxyphenyl)Methanol

Chemical Property:

• Boiling Point: 458.4±45.0 °C(Predicted)
• PKA: 11.92±0.20(Predicted)
• PSA: 70.59000
• Density: 1.305±0.06 g/cm3(Predicted)
• LogP: 3.38660

Purity/Quality:

97% ^*data from raw suppliers

Benzo[d]thiazol-2-yl(4-methoxyphenyl)methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[D]Thiazol-2-Yl(4-Methoxyphenyl)Methanol

There total 1 articles about Benzo[D]Thiazol-2-Yl(4-Methoxyphenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,3-Benzothiazole (95-16-9) + 4-methoxy-benzaldehyde (123-11-5) → α-(2-benzothiazolyl)-4-methoxybenzyl alcohol (413606-87-8)

Guidance literature:

1,3-Benzothiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h; Inert atmosphere;

4-methoxy-benzaldehyde; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c8ob02221f

Reference yield: 97.0%

α-(2-benzothiazolyl)-4-methoxybenzyl alcohol (413606-87-8) + benzyl bromide (100-39-0) → 2-((benzyloxy)(4-methoxyphenyl)methyl)benzo[d]thiazole

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In tetrahydrofuran; at -25 - 20 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c04109

Reference yield: 85.0%

α-(2-benzothiazolyl)-4-methoxybenzyl alcohol (413606-87-8) + Cinnamyl bromide (4392-24-9) → 2-((cinnamyloxy)(4-methoxyphenyl)methyl)benzo[d]thiazole

Guidance literature:

α-(2-benzothiazolyl)-4-methoxybenzyl alcohol; With sodium hydroxide; In acetone; for 0.0833333h; Inert atmosphere;

Cinnamyl bromide; In acetone; at -20 ℃; for 48h; Inert atmosphere;

DOI:10.1039/c8ob02221f

upstream raw materials:

1,3-Benzothiazole

4-methoxy-benzaldehyde

Refernces

• 1、 Nutaitis, Charles F.,Swartz, Brett D.. "Reduction of π-deficient heterocyclic secondary carbinols with sodium borohydride/trifluoroacetic acid". . p. 507 - 511. Retrieved 2007/10/03.