N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine

Base Information

• Chemical Name: N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine
• CAS No.: 41839-69-4
• Molecular Formula: C12H21NSi
• Molecular Weight: 207.391
• DSSTox Substance ID: DTXSID00566257
• Wikidata: Q82451793
• Mol file: 41839-69-4.mol

Synonyms:41839-69-4;N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine;N,N-Dimethyl-1-[2-(trimethylsilyl)phenyl]methanamine;DTXSID00566257

Chemical Property of N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 207.144326209
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=CC=CC=C1[Si](C)(C)C

Technology Process of N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine

There total 4 articles about N,N-Dimethyl-1-(2-(trimethylsilyl)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

chloro-trimethyl-silane (75-77-4) + 2-bromo-N,N-dimethylbenzylamine (1976-04-1) → N,N-Dimethyl-1-<2-(trimethylsilyl)phenyl>methanamin (41839-69-4)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane; at 20 ℃; for 2h;

DOI:10.1021/ol052113z

Reference yield: 92.0%

chloro-trimethyl-silane (75-77-4) + 2-(N,N-dimethylaminomethyl)phenyllithium (56174-66-4) → N,N-Dimethyl-1-<2-(trimethylsilyl)phenyl>methanamin (41839-69-4)

Guidance literature:

In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1016/0022-328X(94)87166-3

Reference yield: 82.0%

N,N'-dimethylbenzylamine (103-83-3) + chloro-trimethyl-silane (75-77-4) → N,N-Dimethyl-1-<2-(trimethylsilyl)phenyl>methanamin (41839-69-4)

Guidance literature:

N,N'-dimethylbenzylamine; With Quinuclidine; trimethylsilylmethyllithium; In n-heptane; at 0 ℃; for 5h; Inert atmosphere; Reflux;

chloro-trimethyl-silane; In n-heptane; at -50 - 22 ℃; Inert atmosphere;

DOI:10.1039/c9dt02182e

upstream raw materials:

N,N'-dimethylbenzylamine

chloro-trimethyl-silane

2-(N,N-dimethylaminomethyl)phenyllithium

2-bromo-N,N-dimethylbenzylamine

Downstream raw materials:

(2-methylphenyl)trimethylsilane

1,2-bis(2-trimethylsilanylphenyl)ethane

2-(trimethylsilyl)benzyl 3-iodobenzoate

1-dimethylamino-1,2-di(methoxycarbonyl)ethene