Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate

Base Information

Chemical Name:Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate
CAS No.:4192-32-9
Molecular Formula:C₈H₇BrO₃S
Molecular Weight:263.112
Hs Code.:2934999090
European Community (EC) Number:825-766-0
DSSTox Substance ID:DTXSID40547767
Wikidata:Q82426211
Mol file:4192-32-9.mol

Synonyms:4192-32-9;Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate;5-(2-Bromo-acetyl)-thiophene-2-carboxylic acid methyl ester;5-(2-Bromoacetyl)thiophene-2-carboxylic acid methyl ester;Methyl 5-(bromoacetyl)thiophene-2-carboxylate;2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone;SCHEMBL277652;DTXSID40547767;KKPYVZJBLYIYRX-UHFFFAOYSA-N;MFCD13191387;AKOS022172501;AS-48198;CS-0217630;EN300-80316;methyl 5-(bromoacetyl)-2-thiophenecarboxylate;F19715;Methyl5-(2-bromoacetyl)thiophene-2-carboxylate

Suppliers and Price of Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-(2-bromoacetyl)thiophene-2-carboxylate 95+%
1g
$ 535.00

Chemenu
methyl5-(2-bromoacetyl)thiophene-2-carboxylate 95%
1g
$ 505.00

Chemcia Scientific
5-(2-Bromo-acetyl)-thiophene-2-carboxylicacidmethylester ＞97%
0.25 G
$ 250.00

Arctom
Methyl5-(2-bromoacetyl)thiophene-2-carboxylate ≥95%
1g
$ 596.00

Alichem
Methyl5-(2-bromoacetyl)thiophene-2-carboxylate
1g
$ 453.44

Total 11 raw suppliers

Chemical Property of Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate

Chemical Property:

Melting Point:122-123 °C
Boiling Point:375.6±32.0 °C(Predicted)
PSA：71.61000
Density:1.628±0.06 g/cm3(Predicted)
LogP:2.11230
Storage Temp.:2-8°C
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:261.92993
Heavy Atom Count:13
Complexity:219

Purity/Quality:

96%min ^*data from raw suppliers

Methyl5-(2-bromoacetyl)thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC=C(S1)C(=O)CBr

Technology Process of Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate

There total 7 articles about Methyl 5-(2-bromoacetyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4101-81-9
methyl 5-acetyl-2-thiophenecarboxylate

: 4192-32-9
2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone

Guidance literature:: With copper(ll) bromide; In ethyl acetate; for 6h; Heating / reflux;

Reference yield:

: 4066-41-5
5-acetylthiophene-2-carboxylic acid

: 4192-32-9
2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 20 °C

2: bromine / 1,4-dioxane / 1.5 h / 20 °C

With bromine; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 4565-31-5
5-formyl-2-thiophencarboxylic acid

: 4192-32-9
2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Na₂CO₃ / dimethylformamide / Ambient temperature

2: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature

3: SOCl₂ / 1.5 h / Heating

4: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min

With thionyl chloride; jones reagent; hydrogen bromide; sodium carbonate; In N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570280104