4066-41-5Relevant articles and documents
Photo-induced deep aerobic oxidation of alkyl aromatics
Wang, Chang-Cheng,Zhang, Guo-Xiang,Zuo, Zhi-Wei,Zeng, Rong,Zhai, Dan-Dan,Liu, Feng,Shi, Zhang-Jie
, p. 1487 - 1492 (2021/07/10)
Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].
A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method
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Paragraph 0028; 0029, (2017/08/25)
The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.
Friedel-Crafts acylation with malonic acids in polyphosphoric acid
Renault, Olivier,Dallemagne, Patrick,Rault, Sylvain
, p. 324 - 328 (2007/10/03)
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