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4066-41-5Relevant academic research and scientific papers
Photo-induced deep aerobic oxidation of alkyl aromatics
Wang, Chang-Cheng,Zhang, Guo-Xiang,Zuo, Zhi-Wei,Zeng, Rong,Zhai, Dan-Dan,Liu, Feng,Shi, Zhang-Jie
, p. 1487 - 1492 (2021/07/10)
Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].
A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method
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Paragraph 0028; 0029, (2017/08/25)
The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.
Preparation of new polyfunctional magnesiated heterocycles using a chlorine-, bromine-, or iodine-magnesium exchange
Abarbri, Mohamed,Thibonnet, Jerome,Berillon, Laurent,Dehmel, Florian,Rottlaender, Mario,Knochel, Paul
, p. 4618 - 4634 (2007/10/03)
The reaction of heteroaryl iodides with i-PrMgBr (ca. 1.0 equiv) in THF provides the corresponding magnesiated heterocycles. Functional groups such as an ester, cyano, or chloride functions are tolerated in these new Grignard reagents if the exchange can be performed below -20 °C. This is the case for all heterocycles bearing electron-withdrawing groups or chelating functions facilitating the iodine-magnesium exchange. In many cases, the exchange can be extended to heteroaryl bromides, and a case of a chlorine-magnesium exchange is described with tetrachlorothiophene. This new preparation of functionalized heteroarylmagnesium compounds provides after reaction with various electrophiles a new entry to a broad range of polyfunctional pyridines, imidazoles, furanes, thiophenes, pyrroles, antipyrines, and uracil derivatives. The application of the halogenmagnesium exchange in the solid phase allows the performance of solid-phase synthesis, with potential applications for combinatorial chemistry.
Phosphorylamides, their preparation and use
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, (2008/06/13)
A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.
Thiophene derivatives and methods for producing the same
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, (2008/06/13)
Novel compounds, 2-(α-alkoxyimino)ethylthiophenes are susceptible to electrophilic substitution reactions, and the acetylation, nitration, sulfonation and halogenation of the compounds provide 5-acetyl-2-(α-alkoxyimino)ethylthiophenes, 5-nitro-2-(α-alkoxyimino)ethylthiophenes, 5-(α-alkoxyimino)ethyl-2-thiophenesulfonic acid and 5-halo-2-(α-alkoxyimino)ethylthiophenes, respectively. The hydrolysis of 5-acetyl-2-(α-alkoxyimino)ethylthiophenes readily provides a known compound, 2,5-diacetylthiophene which is an important intermediate for the production of medicines, whereas the haloform reaction provides novel compounds, 5-(α-alkoxyimino)ethyl-2-thiophenecarboxylic acids, the hydrolysis of which compounds readily provides a known compound, 5-acetyl-2-thiophenecarboxylic acids, an important intermediate for the production of medicines. The hydrolysis of 5-(α-alkoxyimino)ethyl-2-thiophenesulfonic acids and their salts provide novel 5-acetyl-2-thiophenesulfonic acid and its salts, respectively. Novel compounds, 2-(α-alkoxyimino)ethylthiophenes are obtained either by 0-alkylation of 2-acetylthiophene oxime or by directly reacting 2-acetylthiophene with an 0-alkylhydroxylamine.
LIQUID-PHASE OXIDATION OF METHYLACETOTHIENONES WITH COBALT-BROMIDE CATALYST
Kazakova, O. A.,Volkov, M. N.,Konstantinov, P. A.
, p. 431 - 434 (2007/10/02)
The oxidation of four isomeric methylacetothienones by molecular oxygen in acetic acid in the presence of cobalt-bromide catalyst was investigated.The reaction leads to the formation of the corresponding keto carboxylic acid.The keto aldehydes are intermediate products.
