2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI)

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI)
• CAS No.: 133380-41-3
• Molecular Formula: C7H5ClO3S
• Molecular Weight: 204.634
• Mol file: 133380-41-3.mol

Synonyms:2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI)

Chemical Property of 2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI)

Chemical Property:

• PSA: 71.61000
• LogP: 1.91370

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI)

There total 6 articles about 2-Thiophenecarboxylic acid, 5-(chlorocarbonyl)-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium 5-(methoxycarbonyl)-thiophene-2-carboxylate (1257585-84-4) → methyl 5-(chlorocarbonyl)thiophene-2-carboxylate (133380-41-3)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 90 ℃; for 1h; Reflux;

Reference yield:

thiophene-2,5-dicarboxylic acid monomethyl ester (50340-79-9) → methyl 5-(chlorocarbonyl)thiophene-2-carboxylate (133380-41-3)

Guidance literature:

With thionyl chloride; for 1.5h; Heating;

DOI:10.1002/jhet.5570280104

Reference yield:

methanol (67-56-1) + thiophene-2,5-dicarbonyl dichloride (3857-36-1) → methyl 5-(chlorocarbonyl)thiophene-2-carboxylate (133380-41-3)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 1h; Cooling with ice;

upstream raw materials:

thiophene-2,5-dicarboxylic acid monomethyl ester

5-formyl-2-thiophencarboxylic acid

5-formyl-thiophene-2-carboxylic acid methyl ester

Dimethyl thiophene-2,5-dicarboxylate

Downstream raw materials:

C₁₇H₂₂N₄O₆S₂

C₂₅H₃₄N₆O₅S

C₂₀H₂₆N₆O₃S

C₂₉H₂₈Cl₂N₄O₇S₃

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER". . . Retrieved 2012/04/23.
• 2、 -. "THIOPHENE -2- CARBOXYLIC ACID - (1H - BENZIMIDAZOL - 2 YL) - AMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE TEC KINASE ITK (INTERLEUKIN -2- INDUCIBLE T CELL KINASE) FOR THE TREATMENT OF INFLAMMATION, IMMUNOLOGICAL AND ALLERGIC DISORDERS". Page/Page column 123-125. . Retrieved 2010/02/13.