3-Ethylpyridin-2-amine

Base Information

• Chemical Name: 3-Ethylpyridin-2-amine
• CAS No.: 42753-67-3
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10453301
• Wikidata: Q72436924
• Mol file: 42753-67-3.mol

Synonyms:3-ethylpyridin-2-amine;42753-67-3;3-Ethyl-pyridin-2-ylamine;2-AMINO-3-ETHYLPYRIDINE;3-ethyl-2-Pyridinamine;3-Ethylpyridin-2-ylamine;2-Pyridinamine,3-ethyl-;3-ethylpyridine-2-amine;3-Ethyl-2-aminopyridine;CHEMPACIFIC 38169;SCHEMBL293456;DTXSID10453301;WTAZAHLROWIQRC-UHFFFAOYSA-N;BCP11445;MFCD07774120;AKOS013407835;SB37163;TS-01619;AM20051175;CS-0172214;FT-0668381;EN300-116427;A872827;J-512438;Z1192017773

Chemical Property of 3-Ethylpyridin-2-amine

Chemical Property:

• Boiling Point: 235.511 °C at 760 mmHg
• PKA: 7.19±0.36(Predicted)
• Flash Point: 119.229 °C
• PSA: 38.91000
• Density: 1.037 g/cm³
• LogP: 1.80740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

97% ^*data from raw suppliers

3-Ethyl-2-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(N=CC=C1)N
• Uses: As a pyridine derivative, 3-Ethyl-2-pyridinaMine can be used in the preparation of glutaramides as potential inhibitors of neutral endopeptidase. A pyridine derivative used in the preparation of glutaramides as potential inhibitors of neutral endopeptidase.

Technology Process of 3-Ethylpyridin-2-amine

There total 19 articles about 3-Ethylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-Amino-3-bromopyridine (13534-99-1) + diethylzinc (557-20-0) → 2-amino-3-ethylpyridine (42753-67-3)

Guidance literature:

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In 1,4-dioxane; for 24h; Reflux; Inert atmosphere;

DOI:10.1002/anie.201915624

Reference yield:

→ 2-amino-3-ethylpyridine (42753-67-3) + isopropyl benzoate (939-48-0)

Guidance literature:

With Zn⁽²⁺⁾*2C₂H₃O₂^(1-)*17H₂O; at 75 ℃; for 6h;

Reference yield:

pyridine (110-86-1) + 3-ethylpyridine N-oxide (14906-62-8) + trifluoroacetic anhydride (407-25-0) → 2-amino-3-ethylpyridine (42753-67-3) + 5-ethylpyridin-2-yl amine (19842-07-0)

Guidance literature:

pyridine; 3-ethylpyridine N-oxide; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃;

With hydrazine hydrate; In ethanol; at 80 ℃; for 2h; Overall yield = 90 percent; Overall yield = 92 mg;

DOI:10.1055/s-0040-1719865

upstream raw materials:

3-ethylpyridine

7-Azaindole

tert-butyl (3-ethylpyridin-2-yl)carbamate

3-ethenyl-2-nitropyridine

Downstream raw materials:

2-[1-(3-ethyl-pyridin-2-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid benzyl ester

5-bromo-3-ethylpyridin-2-amine

2-chloro-3-ethylpyridine