2-Methoxy-11H-indolo[3,2-c]quinoline

Base Information

• Chemical Name: 2-Methoxy-11H-indolo[3,2-c]quinoline
• CAS No.: 4295-45-8
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.27900
• Hs Code.: 2933990090
• Mol file: 4295-45-8.mol

Synonyms:

Chemical Property of 2-Methoxy-11H-indolo[3,2-c]quinoline

Chemical Property:

• PSA: 37.91000
• LogP: 3.87790
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Methoxy-11H-indolo[3,2-c]quinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-11H-indolo[3,2-c]quinoline

There total 17 articles about 2-Methoxy-11H-indolo[3,2-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(3E)-4-[2-(4-methoxy-2-nitrophenyl)-1H-indol-3-yl]but-3-en-2-one (1396307-64-4) → 2-Methoxy-11H-benzo-γ-carbolin (4295-45-8)

Guidance literature:

With iron; acetic acid; for 0.0833333h; Reflux;

DOI:10.1039/c2ob25836f

Reference yield: 71.0%

2-Amino-5-methoxyacetophenone phenylhydrazone (134019-42-4) → 2-Methoxy-11H-benzo-γ-carbolin (4295-45-8)

Guidance literature:

With 1,3,5-Triazine; at 100 - 130 ℃; for 2h;

DOI:10.1021/acs.joc.6b03084

Reference yield: 67.0%

1-(2-amino-5-methoxy-phenyl)-ethanone (23042-77-5) + phenylhydrazine (100-63-0) → 2-Methoxy-11H-benzo-γ-carbolin (4295-45-8)

Guidance literature:

1-(2-amino-5-methoxy-phenyl)-ethanone; phenylhydrazine; at 120 ℃; for 0.166667h;

With 1,3,5-Triazine; at 100 - 130 ℃; for 2h;

DOI:10.1021/acs.joc.6b03084

upstream raw materials:

4-benzotriazol-1-yl-6-methoxy-quinoline

6-methoxy-2,3-dihydroquinolin-4(1H)-one

phenylhydrazine hydrochloride

phenylhydrazine

Refernces

• 1、 Aksenov, Alexander V.,Aksenov, Dmitrii A.,Orazova, Naila A.,Aksenov, Nicolai A.,Griaznov, Georgii D.,De Carvalho, Annelise,Kiss, Robert,Mathieu, Véronique,Kornienko, Alexander,Rubin, Michael. "One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine". . p. 3011 - 3018. Retrieved 2017/03/23.
• 2、 He, Ling,Chang, He-Xi,Chou, Ting-Chao,Savaraj, Niramol,Cheng. "Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern - Synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives". . p. 101 - 107. Retrieved 2007/10/03.