Technology Process of Phosphonic acid,
[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]cyclopropyl]oxy]methyl]-,
bis(1-methylethyl) ester
There total 2 articles about Phosphonic acid,
[[[1-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]cyclopropyl]oxy]methyl]-,
bis(1-methylethyl) ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium iodide; lithium tert-butoxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
DOI:10.1021/jm0305265
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / Ti(Oi-Pr)4 / tetrahydrofuran / 5 h / -10 - 25 °C
2: 70 percent / LiI; LiOt-Bu / tetrahydrofuran; dimethylformamide / 4 h / 60 °C
With
titanium(IV) isopropylate; lithium iodide; lithium tert-butoxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1: Kulinkovich cyclopropanation;
DOI:10.1021/jm0305265
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 82 percent / NH4F / methanol / 4 h / Heating
2.1: 85 percent / triethylamine / CH2Cl2 / 0.5 h / 25 °C
3.1: NaH / dimethylformamide / 0.5 h / 25 °C
3.2: 39 percent / dimethylformamide / 4 h / 80 °C
4.1: 94 percent / H2 / Pd/C / tetrahydrofuran / 18 h / 1 Torr
5.1: 89.5 percent / trimethylsilyl bromide / CH2Cl2 / 18 h / Heating
6.1: triethylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C
6.2: 38.5 percent / 1-methyl-pyrrolidin-2-one / 48 h / 25 °C
With
ammonium fluoride; trimethylsilyl bromide; hydrogen; sodium hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0305265
