4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

Base Information

• Chemical Name: 4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78
• CAS No.: 442199-16-8
• Molecular Formula: C14H20ClN3O3
• Molecular Weight: 313.784
• Mol file: 442199-16-8.mol

Synonyms:tert-Butyl 4-((6-chloropyridazin-3-yl)oxy)piperidine-1-carboxylate;tert-butyl 4-[(6-chloro-3-pyridazinyl)oxy]-1-piperidinecarboxylate;F2145-0120;4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

Chemical Property:

• PSA: 64.55000
• Density: 1.242
• LogP: 2.84620

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-[(6-chloropyridazin-3-yl)oxy]piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

There total 2 articles about 4-(6-Chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3,6-dichlorpyridazine (141-30-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(6-chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (442199-16-8)

Guidance literature:

1-(tert-Butyloxycarbonyl)-4-piperidinol; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 0.0833333h;

3,6-dichloro-pyridazine; In tetrahydrofuran; dimethyl sulfoxide; at 50 ℃; Sealed tube;

DOI:10.1016/j.bmc.2016.03.009

Reference yield:

→ 4-(6-chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (442199-16-8) + 5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide (442198-33-6)

Guidance literature:

Reference yield: 74.0%

Benzophenone imine (1013-88-3) + 4-(6-chloro-pyridazin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (442199-16-8) → 4-[6-(benzhydrylidene-amino)-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene; at 90 - 120 ℃; Sealed tube; Inert atmosphere;

DOI:10.1016/j.bmc.2016.03.009

upstream raw materials:

3,6-dichlorpyridazine

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-3-pyridazinyl)-oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide

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