CYCLOBUTYLACETONITRILE

Base Information

• Chemical Name: CYCLOBUTYLACETONITRILE
• CAS No.: 4426-03-3
• Molecular Formula: C6H9N
• Molecular Weight: 95.1442
• Hs Code.: 2926909090
• Mol file: 4426-03-3.mol

Synonyms:Cyclobutylacetonitrile;Cyclobutanethannitril;Cyclobutaneacetonitrile;2-cyclobutylethanenitrile;Cyclobutylacetonitril;

Chemical Property of CYCLOBUTYLACETONITRILE

Chemical Property:

• Vapor Pressure: 0.86mmHg at 25°C
• Boiling Point: 181.2oC at 760 mmHg
• Flash Point: 70.1oC
• PSA: 23.79000
• Density: 0.933g/cm3
• LogP: 1.70018
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Cyclobutylacetonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOBUTYLACETONITRILE

There total 17 articles about CYCLOBUTYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(Bromomethyl)cyclobutane (17247-58-4) + sodium cyanide (773837-37-9) → cyclobutyl acetonitrile (4426-03-3)

Guidance literature:

In dimethyl sulfoxide; at 60 - 70 ℃; for 3h;

Reference yield: 82.0%

cyclobutylmethyl 4-methylbenzenesulfonate (13295-53-9) + sodium cyanide (143-33-9,25596-52-5) → cyclobutyl acetonitrile (4426-03-3)

Guidance literature:

In dimethyl sulfoxide; at 130 ℃; for 1.5h;

Reference yield: 70.0%

(Bromomethyl)cyclobutane (17247-58-4) + potassium cyanide → cyclobutyl acetonitrile (4426-03-3)

Guidance literature:

In dimethyl sulfoxide; at 140 ℃; for 5h; Inert atmosphere;

upstream raw materials:

cyclobutylmethyl 4-methylbenzenesulfonate

sodium cyanide

cyclobutylmethyl methanesulfonate

(Bromomethyl)cyclobutane

Downstream raw materials:

cyclobutylacetic acid

2-cyclobutylacetaldehyde

ethyl 4-cyclobutyl-3-oxobutanoate

4-cyclobutyl-1-ethoxy-1,3-dioxobutan-2-yl 4-methoxybenzoate

Refernces

• 1、 Mizzoni et al.. "". . p. 878,880. Retrieved 1970.
• 2、 Muratov, Karim,Kuchuk, Ekaterina,Vellalath, Sreekumar,Afanasyev, Oleg I.,Moskovets, Alexei P.,Denisov, Gleb,Chusov, Denis. "Formal reductive addition of acetonitrile to aldehydes and ketones". supporting information. p. 7693 - 7701. Retrieved 2018/11/02.
• 3、 -. "Piperazine derivatives and their use as therapeutic agents". . . Retrieved 2016/03/19.