4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER
• CAS No.: 885280-12-6
• Molecular Formula: C10H16 O3
• Molecular Weight: 184.235
• Hs Code.: 2918300090
• Mol file: 885280-12-6.mol

Synonyms:ETHYL 4-CYCLOBUTYL-3-OXOBUTANOATE;4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER

Chemical Property of 4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER

Chemical Property:

• PSA: 43.37000
• LogP: 1.69890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-Cyclobutyl-3-oxobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER

There total 3 articles about 4-CYCLOBUTYL-3-OXO-BUTYRIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutyl acetonitrile (4426-03-3) + ethyl bromoacetate (105-36-2) → ethyl 4-cyclobutyl-3-oxobutanoate (885280-12-6)

Guidance literature:

cyclobutyl acetonitrile; ethyl bromoacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 70 ℃; for 4h; Inert atmosphere; Large scale;

With sulfuric acid; water; In tetrahydrofuran; at 20 ℃; for 1h; Large scale;

Reference yield:

cyclobutylmethyl methanesulfonate (63659-30-3) → ethyl 4-cyclobutyl-3-oxobutanoate (885280-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 4.67 h / 85 °C / Inert atmosphere; Large scale

2.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere; Large scale

2.2: 1 h / 20 °C / Large scale

With chloro-trimethyl-silane; zinc; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

cyclobutanemethanol (4415-82-1) → ethyl 4-cyclobutyl-3-oxobutanoate (885280-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 4.17 h / -10 - -5 °C / Large scale

2.1: dimethyl sulfoxide / 4.67 h / 85 °C / Inert atmosphere; Large scale

3.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere; Large scale

3.2: 1 h / 20 °C / Large scale

With chloro-trimethyl-silane; triethylamine; zinc; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

cyclobutyl acetonitrile

ethyl bromoacetate

cyclobutylmethyl methanesulfonate

cyclobutanemethanol

Downstream raw materials:

4-cyclobutyl-1-ethoxy-1,3-dioxobutan-2-yl 4-methoxybenzoate

(2E)-3-amino-4-cyclobutyl-1-ethoxy-1-oxobut-2-en-2-yl 4-methoxybenzoate

3-[(tert-butoxycarbonyl)amino]-4-cyclobutyl-1-ethoxy-1-oxobut-2-yl 4-methoxybenzoate

tert-butyl 4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-ylcarbamate

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