Cyclohexanemethanol, a-hexyl-

Base Information

• Chemical Name: Cyclohexanemethanol, a-hexyl-
• CAS No.: 4436-87-7
• Molecular Formula: C13H26O
• Molecular Weight: 198.349
• Mol file: 4436-87-7.mol

Synonyms:

Chemical Property of Cyclohexanemethanol, a-hexyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanemethanol, a-hexyl-

There total 5 articles about Cyclohexanemethanol, a-hexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

n-hexylmagnesium bromide (3761-92-0) + cyclohexanecarbaldehyde (2043-61-0) → 1-cyclohexylheptan-1-ol (4436-87-7)

Guidance literature:

n-hexylmagnesium bromide; With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.75h; Inert atmosphere;

cyclohexanecarbaldehyde; In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo100563p

Reference yield: 70.0%

(E)-C6H11CH(OH)CHC(n-Bu)SnBu3 (130708-13-3,138154-01-5) → 1-cyclohexylheptan-1-ol (4436-87-7) + C6H11CH(OH)CH2CH(n-Bu)SnBu3 (138407-98-4)

Guidance literature:

With hydrogen; {(1,4-bis(diphenylphosphino)butane)Rh(norbornadiene)}BF₄; In dichloromethane; for 36h; under 72005.7 Torr;

Reference yield: 45.0%

(Z)-1-Cyclohexyl-3-(tributylstannyl)hept-2-enol (138154-01-5,130708-13-3) → 1-cyclohexylheptan-1-ol (4436-87-7)

Guidance literature:

With hydrogen; {(1,4-bis(diphenylphosphino)butane)Rh(norbornadiene)}BF₄; In dichloromethane; for 48h; under 77572.2 Torr;

DOI:10.1021/jo00100a023

upstream raw materials:

heptanal

cyclohexylmagnesium bromide

n-hexylmagnesium bromide

cyclohexanecarbaldehyde

Downstream raw materials:

Phosphoric acid (E)-2-benzenesulfonyl-1-cyclohexyl-hept-1-enyl ester diethyl ester

2-Benzenesulfonyl-1-cyclohexyl-heptan-1-one

1-Cyclohexyl-2-phenylsulfanyl-heptan-1-one

n-pentylcyclohexylacetylene

Refernces

• 1、 Suzuki, Keisuke,Hasegawa, Takayuki,Imai, Takahiro,Maeta, Hideki,Ohba, Shigeru. "AgAsF6 as safe alternative to AgClO4 for generating cationic zirconocene species: Utilities in Lewis acid-promoted selective C---C bond forming reactions". . p. 4483 - 4494. Retrieved 2007/10/02.
• 2、 Lautens, Mark,Zhang, ChunHao,Crudden, Cathleen M.. "Durch eine Hydroxygruppe gesteuerte Hydrierung von Vinylstannanen und -silanen: ein hochdiastereoselektiver Weg zu β-Stannyl- und β-Silylalkoholen". . p. 237 - 239. Retrieved 2007/10/02.