2-Fluoro-6-(hydroxymethyl)phenol

Base Information

• Chemical Name: 2-Fluoro-6-(hydroxymethyl)phenol
• CAS No.: 446-58-2
• Molecular Formula: C7H7FO2
• Molecular Weight: 142.13
• DSSTox Substance ID: DTXSID401298781
• Mol file: 446-58-2.mol

Synonyms:2-fluoro-6-(hydroxymethyl)phenol;446-58-2;2-fluoro-6-hydroxymethylphenol;SCHEMBL1941757;2-fluoro-6-hydroxymethyl-phenol;3-Fluoro-2-hydroxybenzenemethanol;ILYRXJYIZJVXER-UHFFFAOYSA-N;DTXSID401298781;MFCD06202611;AKOS006293250;SB84516;DB-050718;CS-0353756;E97752;EN300-1853105;A847073

Chemical Property of 2-Fluoro-6-(hydroxymethyl)phenol

Chemical Property:

• PSA: 40.46000
• LogP: 1.02360
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.04300762
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-6-(hydroxymethyl)phenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)F)O)CO

Technology Process of 2-Fluoro-6-(hydroxymethyl)phenol

There total 2 articles about 2-Fluoro-6-(hydroxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluorosalicylaldehyde (394-50-3) → 2-fluoro-6-hydroxymethyl-phenol (446-58-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-fluorophenol (367-12-4) → 2-fluoro-6-hydroxymethyl-phenol (446-58-2)

Guidance literature:

With sodium metaborate tetrahydrate; In water; at 40 ℃; for 12h; regioselective reaction; Green chemistry;

DOI:10.1039/c4ob00228h

Reference yield: 75.0%

2-fluoro-6-hydroxymethyl-phenol (446-58-2) + acetic anhydride (108-24-7) → C11H11FO4 (343-50-0)

Guidance literature:

for 16h; Heating / reflux;

upstream raw materials:

3-fluorosalicylaldehyde

formaldehyd

2-fluorophenol

Downstream raw materials:

(3-fluoro-2-hydroxyphenyl)acetonitrile

C₁₁H₁₁FO₄