Benzoic acid, 4-hydrazino-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-hydrazino-, methyl ester
• CAS No.: 4510-12-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2928000090
• Mol file: 4510-12-7.mol

Synonyms:4-Methoxycarbonyl-phenylhydrazin;4-hydrazinobenzoic acid methyl ester;4-carbomethoxyphenyl hydrazine;methyl 4-hydrazinobenzoate;

Chemical Property of Benzoic acid, 4-hydrazino-, methyl ester

Chemical Property:

• PSA: 64.35000
• LogP: 1.53210

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-hydrazinylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-hydrazino-, methyl ester

There total 4 articles about Benzoic acid, 4-hydrazino-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.53%

4-methoxycarbonyl aniline (619-45-4) → methyl 4-hydrazinobenzoate (4510-12-7)

Guidance literature:

4-methoxycarbonyl aniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃; for 2h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃; for 2h;

Reference yield: 51.0%

methanol (67-56-1) + 4-Hydrazinobenzoic acid (619-67-0) → methyl 4-hydrazinobenzoate (4510-12-7)

Guidance literature:

With sulfuric acid; for 15h; Heating;

DOI:10.1002/chem.200304820

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → methyl 4-hydrazinobenzoate (4510-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C

2.2: 0 - 20 °C

With hydrogenchloride; sulfuric acid; sodium nitrite; In water;

upstream raw materials:

methanol

4-Hydrazinobenzoic acid

4-methoxycarbonyl aniline

4-amino-benzoic acid

Downstream raw materials:

triphenylmethyl alcohol

2-acetyl-1-(methyl 4-phenylcarboxylate)hydrazine

ReCl₂(P(C₆H₅)3)2NCCH₃(N₂C₆H₄CO₂CH₃)

methyl 4-(1-(2-(6-methylpyridin-3-yl)ethyl)hydrazinyl)benzoate

Refernces

• 1、 Wang, Hai-Chao,Yan, Xiao-Qiang,Yan, Tian-Long,Li, Hong-Xia,Wang, Zhong-Chang,Zhu, Hai-Liang. "Design, synthesis and biological evaluation of benzohydrazide derivatives containing dihydropyrazoles as potential EGFR kinase inhibitors". . . Retrieved 2016/08/12.
• 2、 -. "Benzoyl hydrazine derivative containing dihydro-pyrazole structure and preparation method of benzoyl hydrazine derivative". Paragraph 0010; 0011; 0012. . Retrieved 2016/12/22.