2,6-dichloro-4-hydroxybenzoic acid

Base Information

• Chemical Name: 2,6-dichloro-4-hydroxybenzoic acid
• CAS No.: 4641-38-7
• Molecular Formula: C7H4Cl2O3
• Molecular Weight: 207.013
• Hs Code.: 2918290000
• Mol file: 4641-38-7.mol

Synonyms:2,6-dichloro-4-hydroxy-benzoic acid;

Chemical Property of 2,6-dichloro-4-hydroxybenzoic acid

Chemical Property:

• Boiling Point: 362.6±42.0 °C(Predicted)
• PKA: 2.16±0.25(Predicted)
• PSA: 57.53000
• Density: 1.665±0.06 g/cm3(Predicted)
• LogP: 2.39720
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-4-hydroxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dichloro-4-hydroxybenzoic acid

There total 7 articles about 2,6-dichloro-4-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-4-methoxybenzoic acid (94278-69-0) → 2,6-Dichloro-4-hydroxybenzoic acid (4641-38-7)

Guidance literature:

2,6-dichloro-4-methoxybenzoic acid; With boron tribromide; In dichloromethane; at -78 - 25 ℃; for 16h;

With sodium hydroxide; In dichloromethane; water;

With hydrogenchloride; In water; at 0 ℃;

Reference yield:

methyl 4-amino-2,6-dichlorobenzoate (232275-49-9) → 2,6-Dichloro-4-hydroxybenzoic acid (4641-38-7)

Guidance literature:

methyl 4-amino-2,6-dichlorobenzoate; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

In water; for 2h; Heating;

With sodium hydroxide; In tetrahydrofuran; methanol; for 48h; Heating;

DOI:10.1016/S0968-0896(02)00021-4

Reference yield:

2,6-dichloro-4-nitrobenzoic acid (22509-50-8) → 2,6-Dichloro-4-hydroxybenzoic acid (4641-38-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: SOCl₂ / CH₂Cl₂ / 19 h / Heating

2.1: 10.8 g / 17 h / Heating

3.1: 78 percent / Na₂S₂O₄ / ethanol; H₂O / 2 h / Heating

4.1: NaNO₂; HCl / H₂O / 0.5 h / 0 - 5 °C

4.2: H₂O / 2 h / Heating

4.3: 248 mg / NaOH / tetrahydrofuran; methanol / 48 h / Heating

With hydrogenchloride; thionyl chloride; sodium dithionite; sodium nitrite; In ethanol; dichloromethane; water;

DOI:10.1016/S0968-0896(02)00021-4

upstream raw materials:

methyl 4-amino-2,6-dichlorobenzoate

2,6-dichloro-4-nitrobenzoic acid

methyl 2,6-dichloro-4-nitrobenzoate

2,6-dichloro-4-nitrobenzoyl chloride

Refernces

• 1、 -. "Inhibitors of α4 mediated cell adhesion". . . Retrieved 2008/06/13.
• 2、 -. "Piperazine derivatives useful as CCR5 antagonists". Page column 48. . Retrieved 2010/02/05.