Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester
CAS No.:473712-18-4
Molecular Formula:C27H29FN6O2
Molecular Weight:488.565
Hs Code.:
Mol file:473712-18-4.mol

Synonyms:

Suppliers and Price of Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester

There total 8 articles about Carbamic acid, [3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a] pyridin-6-yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-6-carboxylic acid hydrochloride

: 75-65-0
tert-butyl alcohol

: 473712-18-4
tert-butyl 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-ylcarbamate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; for 2.5h; Heating;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

: 473712-18-4
tert-butyl 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / phosphorus oxychloride / 72 h / 20 °C

2.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

3.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

4.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

5.1: sodium / 20 °C

5.2: 92 percent / ethanol / 18 h / 60 °C

6.1: 85 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 2 h / 20 °C

7.1: 92 percent / lithium hydroxide monohydrate; hydrochloric acid / dioxane; H₂O / 5 h / 95 °C

8.1: 54 percent / diphenylphosphoryl azide; triethylamine / 2.5 h / Heating

With hydrogenchloride; manganese(IV) oxide; lithium hydroxide; diphenylphosphoranyl azide; sodium ethanolate; sodium; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; acetone; 1.1: Vilsmeier-Haack formylation / 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 468062-76-2
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 473712-18-4
tert-butyl 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

2.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

3.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

4.1: sodium / 20 °C

4.2: 92 percent / ethanol / 18 h / 60 °C

5.1: 85 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 2 h / 20 °C

6.1: 92 percent / lithium hydroxide monohydrate; hydrochloric acid / dioxane; H₂O / 5 h / 95 °C

7.1: 54 percent / diphenylphosphoryl azide; triethylamine / 2.5 h / Heating

With hydrogenchloride; manganese(IV) oxide; lithium hydroxide; diphenylphosphoranyl azide; sodium ethanolate; sodium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; acetone; 1.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015