1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine

Base Information

• Chemical Name: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine
• CAS No.: 474417-23-7
• Molecular Formula: C12H19N3O2S
• Molecular Weight: 269.368
• Mol file: 474417-23-7.mol

Synonyms:tert-butyl 4-(1,3-thiazol-2-yl)piperazine-1-carboxylate;

Chemical Property of 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine

Chemical Property:

• Vapor Pressure: 5.42E-06mmHg at 25°C
• Boiling Point: 380.5oC at 760 mmHg
• Flash Point: 183.9oC
• PSA: 73.91000
• Density: 1.209g/cm3
• LogP: 2.20310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(thiazol-2-yl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine

There total 3 articles about 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-thiazol-2-yl-piperazine (42270-37-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate (474417-23-7)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00386

Reference yield: 66.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate (474417-23-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield:

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate (77278-40-1) + C7H12AlNS → tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate (474417-23-7)

Guidance literature:

With copper dichloride; In tetrahydrofuran; at 22 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01863

upstream raw materials:

2-bromo-1,3-thiazole

1-t-Butoxycarbonylpiperazine

1-thiazol-2-yl-piperazine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate

tert-butyl 4-(5-methyl-1,3-thiazol-2-yl)-1-piperazinecarboxylate

1-thiazol-2-yl-piperazine

tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate