4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:354587-77-2
Molecular Formula:C₁₃H₁₉N₃O₃S
Molecular Weight:297.378
Hs Code.:2934100090
Mol file:354587-77-2.mol

Synonyms:4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(5-FORMYL-THIAZOL-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00%
5MG
$ 500.71

Total 1 raw suppliers

Chemical Property of 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Vapor Pressure:7.3E-08mmHg at 25°C
Boiling Point:437.7°C at 760 mmHg
Flash Point:218.5°C
PSA：90.98000
Density:1.269g/cm³
LogP:2.01560

Purity/Quality:: 4-(5-FORMYL-THIAZOL-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 464192-28-7
2-bromo-1,3-thiazole-5-carbaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 354587-77-2
tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2007.07.050

Reference yield: 76.0%

: 474417-23-7
tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 354587-77-2
tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate

Guidance literature:: tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00386