4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:623588-36-3
Molecular Formula:C12H18BrN3O2S
Molecular Weight:348.264
Hs Code.:
Mol file:623588-36-3.mol

Synonyms:4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-BROMO-2-(N-BOC-PIPERAZIN-1-YL)THIAZOLE 95.00%
5MG
$ 495.63

Total 2 raw suppliers

Chemical Property of 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Vapor Pressure:1.8E-07mmHg at 25°C
Refractive Index:1.575
Boiling Point:426.2°C at 760 mmHg
Flash Point:211.6°C
PSA：73.91000
Density:1.458g/cm³
LogP:2.96560

Purity/Quality:

99% ^*data from raw suppliers

5-BROMO-2-(N-BOC-PIPERAZIN-1-YL)THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 474417-23-7
tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate

: 623588-36-3
tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate

Guidance literature:: With bromine; caesium carbonate; In chloroform; at 0 - 20 ℃; for 1h;

Reference yield: 83.0%

: 4175-78-4
2,5-dibromo-1,3-thiazole

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 623588-36-3
tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 18h;

Reference yield:

: 42270-37-1
1-thiazol-2-yl-piperazine

: 623588-36-3
tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / acetonitrile / 3 h / 20 °C

2: bromine; caesium carbonate / chloroform / 1 h / 0 - 20 °C

With bromine; caesium carbonate; triethylamine; dmap; In chloroform; acetonitrile;