Benzophenoncyanhydrin

Base Information

• Chemical Name: Benzophenoncyanhydrin
• CAS No.: 4746-48-9
• Molecular Formula: C14H11NO
• Molecular Weight: 209.247
• Mol file: 4746-48-9.mol

Synonyms:Benzilonitril;benzilonitrile;benzophenone cyanohydrine;benzophenone cyanohydrin;Benzilsaeure-nitril;

Chemical Property of Benzophenoncyanhydrin

Chemical Property:

• PSA: 44.02000
• LogP: 2.44608

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzophenoncyanhydrin

There total 12 articles about Benzophenoncyanhydrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

α-hydroperoxy-α,α-diphenylacetonitrile (5233-67-0) + 2,2-diphenyl-1-picrylhydrazine (1707-75-1) → 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (147506-92-1,1898-66-4) + 2-hydroxy-2,2-diphenylacetonitrile (4746-48-9)

Guidance literature:

TPP(Cl)Mn^IIIImH; In dichloromethane; at 25 ℃; Rate constant; variation of ImH and DPPH concentration;

DOI:10.1021/ja00267a039

Reference yield: 75.0%

benzophenone (119-61-9) + trimethylsilyl cyanide (7677-24-9) → 2-hydroxy-2,2-diphenylacetonitrile (4746-48-9)

Guidance literature:

In water; dimethyl sulfoxide; at 20 ℃; for 0.666667h;

DOI:10.1007/s00706-011-0613-4

Reference yield:

2,4,6-tri-tert-butylphenoxol (732-26-3) + α-hydroperoxy-α,α-diphenylacetonitrile (5233-67-0) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + benzophenone (119-61-9) + 2,4,6-tri-tert-butylphenoxyl (3315-32-0,2525-39-5) + 2-hydroxy-2,2-diphenylacetonitrile (4746-48-9) + phenol (108-95-2,27073-41-2)

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; In methanol; dichloromethane; at 25 - 30 ℃; Rate constant; Oxygen transfer to (TPP)Fe(III)(Cl) with/without buffer. Chromium complex also investigated, without TBPH and methanol.;

DOI:10.1021/ja00221a029

upstream raw materials:

nitro-diphenyl-acetonitrile

(α-diphenylmethyl)cyano chloride

2,4,6-tri-tert-butylphenoxol

α-hydroperoxy-α,α-diphenylacetonitrile

Downstream raw materials:

benzophenone

benzilamide

(R)-2-cyclohexyl-4-oxo-4-phenylbutanenitrile

(R)-2-(tert-butyl)-4-oxo-4-phenylbutanenitrile

Refernces

• 1、 Degani, Mariam S.,Kakwani, Manoj D.,Palsule Desai, Nutan H.,Bairwa, Ranjeet. "A single-step, mild, neutral, catalyst-free method for cyanohydrin synthesis". experimental part. p. 461 - 465. Retrieved 2012/06/15.
• 2、 Lee, William A.,Yuan, Lung-Chi,Bruice, Thomas C.. "OXYGEN TRANSFER FROM PERCARBOXYLIC ACIDS AND ALKYL HYDROPEROXIDES TO (MESO-TETRAPHENYLPORPHINATO)IRON(III) AND -CHROMIUM(III)". . p. 4277 - 4283. Retrieved 2007/10/02.