2-Ethyl-4-nitrobenzo[d]oxazole

Base Information

• Chemical Name: 2-Ethyl-4-nitrobenzo[d]oxazole
• CAS No.: 477603-34-2
• Molecular Formula: C9H8N2O3
• Molecular Weight: 192.17100
• Hs Code.: 2934999090
• Mol file: 477603-34-2.mol

Synonyms:2-ethyl-4-nitrobenzoxazole;2-Ethyl-4-nitrobenzo[d]oxazole;

Chemical Property of 2-Ethyl-4-nitrobenzo[d]oxazole

Chemical Property:

• PSA: 71.85000
• LogP: 2.82160
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethyl-4-nitro-1,3-benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-4-nitrobenzo[d]oxazole

There total 1 articles about 2-Ethyl-4-nitrobenzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Amino-3-nitrophenol (603-85-0) + Triethyl orthopropionate (115-80-0) → 2-ethyl-4-nitrobenzo[d]oxazole (477603-34-2)

Guidance literature:

at 100 ℃; for 2h;

DOI:10.1021/ja3083494

Reference yield: 98.0%

2-ethyl-4-nitrobenzo[d]oxazole (477603-34-2) → 4-amino-2-ethylbenzoxazole (477603-35-3)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In methanol; at 20 ℃; for 120h;

Reference yield:

2-ethyl-4-nitrobenzo[d]oxazole (477603-34-2) + methyl 2-(((tertbutoxycarbonyl)oxy)(4-chlorophenyl)methyl)acrylate (1132641-29-2) → (±)methyl 3-(4-chlorophenyl)-2-methylene-4-(4-nitrobenzo[d]oxazol-2-yl)pentanoate + (±)methyl 3-(4-chlorophenyl)-2-methylene-4-(4-nitrobenzo[d]oxazol-2-yl)pentanoate

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; silver(I) acetate; In toluene; at 20 ℃; for 14h; Overall yield = 75 %; Overall yield = 30 mg; diastereoselective reaction;

DOI:10.1039/c4cc00728j

upstream raw materials:

2-Amino-3-nitrophenol

Triethyl orthopropionate

Downstream raw materials:

4-amino-2-ethylbenzoxazole

Refernces

• 1、 -. "CONDENSED HETEROCYCLIC COMPOUND". Paragraph 0270-0272. . Retrieved 2017/11/08.
• 2、 Lavergne, Olivier,Fernandes, Anne-Cecile,Brehu, Laetitia,Sidhu, Alban,Brezak, Marie-Christine,Prevost, Gregoire,Ducommun, Bernard,Contour-Galcera, Marie-Odile. "Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C". . p. 171 - 175. Retrieved 2007/10/03.