1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethanone 1-(O-acetyloxime)

Base Information

• Chemical Name: 1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethanone 1-(O-acetyloxime)
• CAS No.: 478556-66-0
• Molecular Formula: C26H24N2O3
• Molecular Weight: 412.488
• Mol file: 478556-66-0.mol

Synonyms:1-[({1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethylidene}amino)oxy]ethanone;

Chemical Property of 1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethanone 1-(O-acetyloxime)

Chemical Property:

• Vapor Pressure: 1.73E-11mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 534.16 °C at 760 mmHg
• Flash Point: 276.85 °C
• PSA: 60.66000
• Density: 1.179 g/cm³
• LogP: 5.64090

Purity/Quality:

98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethanone 1-(O-acetyloxime)

There total 6 articles about 1-[9-Ethyl-6-(2-methylbenzoyl)-9H-carbazol-3-yl]ethanone 1-(O-acetyloxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

3-acetyl-6-(o-methyl benzoyl)-N-ethylcarbazole (1105615-15-3) + sodium acetate (127-09-3) → ethanone-1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]-1-(O-acetyloxime) (478556-66-0)

Guidance literature:

3-acetyl-6-(o-methyl benzoyl)-N-ethylcarbazole; sodium acetate; With hydroxylamine hydrochloride; tetrabutylammomium bromide; In water; 1,2-dichloro-ethane; at 70 ℃; for 7h;

With toluene-4-sulfonic acid; In water; 1,2-dichloro-ethane; for 6h; Reflux;

DOI:10.1007/s11164-011-0329-4

Reference yield: 80.0%

(6-o-methylbenzoyl-N-ethylcarbazol-3-yl)ethanone oxime + acetic acid (64-19-7,77671-22-8) → ethanone-1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]-1-(O-acetyloxime) (478556-66-0)

Guidance literature:

With boric acid; In water; chlorobenzene; Solvent; Reflux;

Reference yield:

N-ethylcarbazole (86-28-2) → ethanone-1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]-1-(O-acetyloxime) (478556-66-0)

Guidance literature:

Multi-step reaction with 4 steps

1: zirconium catalyst / chlorobenzene / 1 h / 15 - 20 °C

2: chlorobenzene / 0.5 h

3: hydroxylamine hydrochloride; potassium dihydrogenphosphate / water; propan-1-ol / Reflux

4: boric acid / chlorobenzene; water / Reflux

With potassium dihydrogenphosphate; hydroxylamine hydrochloride; boric acid; In propan-1-ol; water; chlorobenzene;

upstream raw materials:

3-acetyl-6-(o-methyl benzoyl)-N-ethylcarbazole

sodium acetate

acetic acid

N-ethylcarbazole