6-Methoxy-2-phenylquinoline

Base Information

• Chemical Name: 6-Methoxy-2-phenylquinoline
• CAS No.: 4789-73-5
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70442130
• Nikkaji Number: J660.719E
• Wikidata: Q82259234
• Mol file: 4789-73-5.mol

Synonyms:6-Methoxy-2-phenylquinoline;4789-73-5;2-Phenyl-6-methoxyquinoline;SCHEMBL5682765;DTXSID70442130;STL289901;AKOS015953421;CCG-356474;SB69866;FT-0763636

Chemical Property of 6-Methoxy-2-phenylquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.91040
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methoxy-2-phenylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(C=C2)C3=CC=CC=C3

Technology Process of 6-Methoxy-2-phenylquinoline

There total 58 articles about 6-Methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2-amino-5-methoxyphenyl)methanol (55414-72-7) + acetophenone (98-86-2) → 2-phenyl-6-methoxyquinoline (4789-73-5)

Guidance literature:

With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); dimethyl sulfoxide; potassium hydroxide; In toluene; at 20 ℃; for 6h;

DOI:10.1039/c9ra04926f

Reference yield: 94.0%

6-methoxy quinoline (5263-87-6) + diphenylzinc (1078-58-6) → 2-phenyl-6-methoxyquinoline (4789-73-5)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; tricyclohexylphosphine; In toluene; at 160 ℃; for 20h; Inert atmosphere;

DOI:10.1002/asia.201100971

Reference yield: 93.0%

6-methoxy-2-phenylquinoline-N-oxide (61845-41-8) → 2-phenyl-6-methoxyquinoline (4789-73-5)

Guidance literature:

With methanol; palladium 10% on activated carbon; ammonium formate; at 20 ℃; Inert atmosphere;

upstream raw materials:

6-methoxy quinoline

phenyllithium

6-methoxyquinoline N-oxide

N-(4-Methoxyphenyl)-3-phenylpropenaldimine

Downstream raw materials:

6-hydroxy-2-phenylquinoline

6-methoxy-1-methyl-2-phenylquinolin-4(1H)-one

1,2,3,4-tetrahydro-6-methoxy-2-phenylquinoline

6-methoxy-2-phenylquinoline-N-oxide