2-(2-Naphthyloxy)-1-chloroethane

Base Information

• Chemical Name: 2-(2-Naphthyloxy)-1-chloroethane
• CAS No.: 3383-79-7
• Molecular Formula: C12H11ClO
• Molecular Weight: 206.672
• NSC Number: 409773
• DSSTox Substance ID: DTXSID30325354
• Wikidata: Q82085706
• Mol file: 3383-79-7.mol

Synonyms:2-(2-chloroethoxy)naphthalene;3383-79-7;2-(2-Naphthyloxy)-1-chloroethane;NSC 409773;NSC409773;O(CCCl)c1ccc2ccccc2c1;SCHEMBL5701247;DTXSID30325354;2-(2-naphthyloxy)-1-chloro ethane;NSC-409773

Chemical Property of 2-(2-Naphthyloxy)-1-chloroethane

Chemical Property:

• Vapor Pressure: 0.000276mmHg at 25°C
• Boiling Point: 332.8°C at 760 mmHg
• Flash Point: 155.6°C
• Density: 1.177g/cm³
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 206.0498427
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)OCCCl

Technology Process of 2-(2-Naphthyloxy)-1-chloroethane

There total 8 articles about 2-(2-Naphthyloxy)-1-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-Bromo-2-chloroethane (107-04-0) + β-naphthol (135-19-3) → 2-(2-naphthyloxy)-1-chloroethane (3383-79-7)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating / reflux;

Reference yield: 91.0%

2-(2-naphthalenyloxy)ethanol (93-20-9) → 2-(2-naphthyloxy)-1-chloroethane (3383-79-7)

Guidance literature:

With pyridine; thionyl chloride; In chloroform; for 12h;

DOI:10.1039/c2ob26995c

Reference yield: 80.0%

β-naphthol (135-19-3) + 2-chloro-ethanol (107-07-3) → 2-(2-naphthyloxy)-1-chloroethane (3383-79-7)

Guidance literature:

With p-toluene sulfonic acid - choline chloride covalently immobilized on polymeric microspheres coated iron oxide magnetic nanoparticles; In neat (no solvent); at 120 ℃; for 12h; chemoselective reaction;

DOI:10.1002/adsc.201800743

upstream raw materials:

2-(2-naphthalenyloxy)ethanol

2-chloroethyl tosylate

β-naphthol

1-Bromo-2-chloroethane

Downstream raw materials:

1-(2-[2]naphthyloxy-ethyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

3-[2-(Naphthalen-2-yloxy)-ethyl]-3H-quinazolin-4-one

ethyl-(2-chloro-ethyl)-(2-[2]naphthyloxy-ethyl)-amine; hydrochloride