2-(2-Nitrophenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(2-Nitrophenyl)-1,3-dioxolane
• CAS No.: 48140-35-8
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2932990090
• NSC Number: 106040
• DSSTox Substance ID: DTXSID10295869
• Nikkaji Number: J1.134.234E
• Wikidata: Q82036066
• Mol file: 48140-35-8.mol

Synonyms:2-(2-Nitrophenyl)-1,3-dioxolane;48140-35-8;MFCD06209042;NSC106040;2-nitrophenyl-1,3-dioxolane;SCHEMBL5486010;DTXSID10295869;CEANTQDUGKFCET-UHFFFAOYSA-N;AB9860;AKOS006293038;1,3-Dioxolane, 2-(2-nitrophenyl)-;2-(2-Nitrophenyl)-1,3-dioxolane #;NSC-106040;AS-44996;SY017224;FT-0752328;A871949

Chemical Property of 2-(2-Nitrophenyl)-1,3-dioxolane

Chemical Property:

• Vapor Pressure: 0.00142mmHg at 25°C
• Boiling Point: 306.2°C at 760 mmHg
• Flash Point: 146.5°C
• PSA: 64.28000
• Density: 1.329g/cm³
• LogP: 2.16340
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 195.05315777
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Nitrophenyl)-1,3-dioxolane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC=CC=C2[N+](=O)[O-]

Technology Process of 2-(2-Nitrophenyl)-1,3-dioxolane

There total 7 articles about 2-(2-Nitrophenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethylene glycol (107-21-1) + 2-nitro-benzaldehyde (552-89-6) → 2-(2-nitrophenyl)-1,3-dioxolane (48140-35-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; Reflux; Inert atmosphere;

DOI:10.1039/b817527f

Reference yield: 98.3%

1-(dimethoxymethyl)-2-nitrobenzene (20627-73-0) + ethylene glycol (107-21-1) → 2-(2-nitrophenyl)-1,3-dioxolane (48140-35-8)

Guidance literature:

With povidone-iodine; In acetonitrile; at 60 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tet.2021.132250

Reference yield: 92.0%

2-nitro-benzaldehyde (552-89-6) + 2-chloro-ethanol (107-07-3) → 2-(2-nitrophenyl)-1,3-dioxolane (48140-35-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -60 ℃; for 1.5h;

DOI:10.1021/ol0613113

upstream raw materials:

ethylene glycol

2-nitro-benzaldehyde

sodium acetoacetonate

2-chloro-ethanol

Downstream raw materials:

3,5-dibromo-2-amino benzaldehyde

ambroxol hydrochloride