2-methylsulfanyl-6-phenyl-1H-pyrimidin-4-one

Base Information

• Chemical Name: 2-methylsulfanyl-6-phenyl-1H-pyrimidin-4-one
• CAS No.: 56035-29-1
• Molecular Formula: C11H10 N2 O S
• Molecular Weight: 218.279
• Hs Code.: 2933599090
• Mol file: 56035-29-1.mol

Synonyms:4(1H)-Pyrimidinone,2-(methylthio)-6-phenyl- (9CI); 4(3H)-Pyrimidinone, 2-(methylthio)-6-phenyl-(6CI); 4-Pyrimidinol, 2-(methylthio)-6-phenyl- (7CI); NSC 48355

Chemical Property of 2-methylsulfanyl-6-phenyl-1H-pyrimidin-4-one

Chemical Property:

• Vapor Pressure: 6.99E-06mmHg at 25°C
• Boiling Point: 377°Cat760mmHg
• Flash Point: 181.8°C
• PSA: 71.31000
• Density: 1.26g/cm³
• LogP: 2.57110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-2-(methylthio)-6-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methylsulfanyl-6-phenyl-1H-pyrimidin-4-one

There total 11 articles about 2-methylsulfanyl-6-phenyl-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-hydroxy-2-mercapto-6-phenylpyrimidine (36822-11-4) + methyl iodide (74-88-4) → 6-phenyl-4-hydroxy-2-methylthiopyrimidine (56035-29-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 16h;

DOI:10.1002/cmdc.201700243

Reference yield: 64.0%

5-benzyloxy-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (63204-39-7) + methyl iodide (74-88-4) → 6-Phenyl-2-S-methylpyrimidine-4-one (56035-29-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 60 ℃;

DOI:10.1016/0223-5234(88)90167-5

Reference yield: 62.3%

2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-methylthio-6-phenyl-3,4-dihydropyrimidin-4-one (56035-29-1) + 2-amino-6-phenyl-1,3-oxazin-4-one (96121-14-1)

Guidance literature:

With potassium hydroxide; In water; for 18h; Ambient temperature;

upstream raw materials:

6-phenyl-2-thiouracil

methyl iodide

2-methylisothiourea sulphate

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

6-phenyluracil

4-chloro-2-(methylthio)-6-phenylpyrimidine

2-hydrazineyl-6-phenylpyrimidin-4(3H)-one

ethyl 1,5-dihydro-5-oxo-1,7-diphenyl-1,2,4-triazolo[4,3-a]pyrimidine-3-carboxylate

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