2H-PYRAN-2-CARBONITRILE, TETRAHYDRO-

Base Information

• Chemical Name: 2H-PYRAN-2-CARBONITRILE, TETRAHYDRO-
• CAS No.: 5397-43-3
• Molecular Formula: C6H9 N O
• Molecular Weight: 111.14176
• Hs Code.: 2932999099
• Mol file: 5397-43-3.mol

Synonyms:Pyran-2-carbonitrile,tetrahydro- (6CI,7CI); 2-Cyanotetrahydropyran; NSC 4206

Chemical Property of 2H-PYRAN-2-CARBONITRILE, TETRAHYDRO-

Chemical Property:

• Vapor Pressure: 5.01E-10mmHg at 25°C
• Boiling Point: 224°Cat760mmHg
• Flash Point: 92.2°C
• PSA: 33.02000
• Density: 1.01g/cm³
• LogP: 1.07908

Purity/Quality:

97% ^*data from raw suppliers

TETRAHYDRO-2H-PYRAN-2-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-PYRAN-2-CARBONITRILE, TETRAHYDRO-

There total 13 articles about 2H-PYRAN-2-CARBONITRILE, TETRAHYDRO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-acetoxytetrahydropyran (2761-33-3) + trimethylsilyl cyanide (7677-24-9) → tetrahydro-2H-pyran-2-carbonitrile (5397-43-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88594-X

Reference yield: 90.0%

trimethylsilyl cyanide (7677-24-9) + 2-chlorotetrahydro-2H-pyran (3136-02-5) → tetrahydro-2H-pyran-2-carbonitrile (5397-43-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88594-X

Reference yield: 80.0%

2-methoxytetrahydropyran (6581-66-4) + trimethylsilyl cyanide (7677-24-9) → tetrahydro-2H-pyran-2-carbonitrile (5397-43-3) + 2-methoxy-6-trimethylsilyloxyhexanenitrile

Guidance literature:

tin(ll) chloride; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)88595-1

upstream raw materials:

3,4-dihydro-2H-pyran

2-methoxytetrahydropyran

trimethylsilyl cyanide

2-acetoxytetrahydropyran

Downstream raw materials:

2-benzyl-2-cyano-3,4,5,6-tetrahydro-2H-pyran

2-benzyl-3,4,5,6-tetrahydro-2H-pyran