2-Methoxytetrahydropyran

Base Information

• Chemical Name: 2-Methoxytetrahydropyran
• CAS No.: 6581-66-4
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Hs Code.: 2932999099
• European Community (EC) Number: 229-509-8
• DSSTox Substance ID: DTXSID90984305
• Nikkaji Number: J43.531G
• Mol file: 6581-66-4.mol

Synonyms:2-methoxytetrahydropyran

Chemical Property of 2-Methoxytetrahydropyran

Chemical Property:

• Vapor Pressure: 12.9mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Boiling Point: 128.5 °C at 760 mmHg
• Flash Point: 25 °C
• PSA: 18.46000
• Density: 0.94 g/cm³
• LogP: 1.15940
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 116.083729621
• Heavy Atom Count: 8
• Complexity: 63.5

Purity/Quality:

98% ^*data from raw suppliers

2-Methoxytetrahydropyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 10
• Safety Statements: 16-29-33

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCCCO1

Technology Process of 2-Methoxytetrahydropyran

There total 52 articles about 2-Methoxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tetrahydro-2-(benzyloxy)-2H-pyran (1927-62-4) → 2-methoxytetrahydropyran (6581-66-4) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With methanol; DOWEX 50 W-X₂ cation exchange resin; at 40 ℃; for 2.66667h;

Reference yield: 97.0%

3,4-dihydro-2H-pyran (110-87-2) + methanol (67-56-1) → 2-methoxytetrahydropyran (6581-66-4)

Guidance literature:

With cobalt benzenesulphonate hexahydrate; acetic acid; at 20 ℃; for 1h;

DOI:10.1515/znb-2010-1109

Reference yield: 96.0%

2-methoxy-3,4-dihydro-2H-pyran (4454-05-1) → 2-methoxytetrahydropyran (6581-66-4)

Guidance literature:

With hydrogen; palladium on activated carbon; at 20 ℃; for 1.5h; under 6000.6 - 15001.5 Torr; Product distribution / selectivity;

upstream raw materials:

3,4-dihydro-2H-pyran

2-(tert-butylperoxy)tetrahydro-2H-pyran

TETRAHYDROPYRANE

methanol

Downstream raw materials:

2-(Tetrahydro-2H-pyran-2-yl)-1-cyclohexanon

tetrahydro-2H-pyran-2-carbonitrile

tetrahydro-2-(phenylseleno)-2H-Pyran

5-Methoxy-5-phenylselanyl-pentan-1-ol