Benzenecarbothioic acid, S-(2-oxo-2-phenylethyl) ester

Base Information

• Chemical Name: Benzenecarbothioic acid, S-(2-oxo-2-phenylethyl) ester
• CAS No.: 49742-23-6
• Molecular Formula: C15H12O2S
• Molecular Weight: 256.325
• Mol file: 49742-23-6.mol

Synonyms:

Chemical Property of Benzenecarbothioic acid, S-(2-oxo-2-phenylethyl) ester

Chemical Property:

• PSA: 59.44000
• LogP: 3.44290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenecarbothioic acid, S-(2-oxo-2-phenylethyl) ester

There total 8 articles about Benzenecarbothioic acid, S-(2-oxo-2-phenylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiobenzoic acid potassium salt (28170-13-0) + α-bromoacetophenone (70-11-1) → 2-oxo-2-phenylethyl 1-benzenecarbothioate (49742-23-6)

Guidance literature:

With silica gel; In benzene; at 20 ℃; for 1h;

DOI:10.1081/SCC-120025193

Reference yield: 82.0%

tributylstannylmethyl thiobenzoate + benzoyl chloride (98-88-4) → 2-oxo-2-phenylethyl 1-benzenecarbothioate (49742-23-6)

Guidance literature:

With copper (II)-fluoride; In 1,4-dioxane; at 102 ℃; for 6h;

DOI:10.1016/j.tetlet.2013.06.088

Reference yield:

Thiobenzoic acid S-(2-oxo-2-phenyl-1-phenylsulfanyl-ethyl) ester (82211-09-4) → 2-oxo-2-phenylethyl 1-benzenecarbothioate (49742-23-6)

Guidance literature:

With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); at 80 - 100 ℃; for 1h;

DOI:10.1016/S0040-4039(00)86855-0

upstream raw materials:

thiobenzoic acid potassium salt

α-bromoacetophenone

2-methylsulfanyl-1,1-bis-trimethylsilanyloxy-ethene

benzoyl chloride

Downstream raw materials:

2,4-diphenylthiazole

bis-[1-(3-methyl-3H-benzothiazol-2-yliden)-2-oxo-2-phenyl-ethyl]-disulfide

dibenzoyl disulfide

acetophenone

Refernces

• 1、 Kagoshima, Hirotaka,Takahashi, Naoshi. "Copper-catalyzed cross-coupling reaction of α-sulfur-substituted alkylstannanes with acid chlorides". . p. 4558 - 4560. Retrieved 2013/08/23.
• 2、 Aoyama, Tadashi,Takido, Toshio,Kodomari, Mitsuo. "A Convenient Synthesis of Thioacetates and Thiobenzoates Using Silica-Gel Supported Potassium Thioacetate". . p. 3817 - 3824. Retrieved 2007/10/03.