N-BENZYL-alpha-phenylethylamine hydrochloride

Base Information

• Chemical Name: N-BENZYL-alpha-phenylethylamine hydrochloride
• CAS No.: 49746-32-9
• Molecular Formula: C15H17N.ClH
• Molecular Weight: 247.768
• Hs Code.: 2921499090
• Mol file: 49746-32-9.mol

Synonyms:

Chemical Property of N-BENZYL-alpha-phenylethylamine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 4.73030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL-alpha-phenylethylamine hydrochloride

There total 4 articles about N-BENZYL-alpha-phenylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

benzonitrile (100-47-0) + acetophenone (98-86-2) → N-benzyl-1-phenylethan-1-aminium chloride (49746-32-9)

Guidance literature:

benzonitrile; acetophenone; With hydrogen; In 2-methyltetrahydrofuran; at 110 ℃; for 20h; under 11251.1 Torr; High pressure; Autoclave;

With hydrogenchloride; In diethyl ether;

DOI:10.1002/chem.202004755

Reference yield:

rac-methylbenzylamine (618-36-0) → N-benzyl-1-phenylethan-1-aminium chloride (49746-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether; H₂O / 3 h

2: 2.) HCl / 1.) ether, THF, RT, 12h 2.) ether

With hydrogenchloride; In diethyl ether; water;

Reference yield:

N-<(benzotriazol-1-yl)methyl>(1-phenylethyl)amine (126541-67-1) + phenylmagnesium bromide → N-benzyl-1-phenylethan-1-aminium chloride (49746-32-9)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) ether, THF, RT, 12h 2.) ether;

upstream raw materials:

N-<(benzotriazol-1-yl)methyl>(1-phenylethyl)amine

rac-methylbenzylamine

benzonitrile

acetophenone

Refernces

• 1、 Katritzky, Alan R.,Glen, Noble,Pilarski, Boguslaw,Harris, Philip. "The N-Substitution of Aliphatic Primary Amines via 1-benzotriazoles: Preparation of Secondary Amines". . p. 1443 - 1446. Retrieved 2007/10/02.