5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester

Base Information

Chemical Name:5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester
CAS No.:497959-45-2
Molecular Formula:C14H23BO3
Molecular Weight:250.14200
Hs Code.:
Mol file:497959-45-2.mol

Synonyms:2-Cyclohexen-1-one,5,5-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);D-1397;

Suppliers and Price of 5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one
2.5g
$ 1320.00

Crysdot
5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-enone 95+%
1g
$ 386.00

Crysdot
5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-enone 95+%
5g
$ 1310.00

American Custom Chemicals Corporation
5,5-DIMETHYLCYCLOHEX-2-EN-1-ONE-3-BORONIC ACID PINACOL ESTER 95.00%
1G
$ 407.40

AK Scientific
5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one
5g
$ 858.00

AK Scientific
5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one
250mg
$ 194.00

Total 10 raw suppliers

Chemical Property of 5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester

Chemical Property:

Boiling Point:278.9±50.0 °C(Predicted)
PSA：35.53000
Density:1.00±0.1 g/cm3(Predicted)
LogP:2.93330

Purity/Quality:

97% ^*data from raw suppliers

5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one is used as a reagent in the synthesis of thiazole carboxamides as PIM kinase inhibitors for treating cancer.

Technology Process of 5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester

There total 4 articles about 5,5-DiMethylcyclohex-2-en-1-one-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 76881-19-1
5,5-dimethyl-3-trifluoromethylsulfonyloxycyclohex-2-en-1-one

: 73183-34-3
bis(pinacol)diborane

: 497959-45-2
1-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-5,5-dimethylcyclohex-1-en-3-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triphenylphosphine; In 1,4-dioxane; for 2 h at 80°C; extd. (C6H6), washed (brine), dried (MgSO4), chromd. (silica gel), distd. (Kugelrohr);
DOI:10.1016/S0022-328X(03)00611-9

Reference yield:

: 126-81-8
dimedone

: 497959-45-2
1-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-5,5-dimethylcyclohex-1-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetramethyl ammoniumhydroxide / hexanes / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium phenolate; triphenylphosphine / toluene / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tetramethyl ammoniumhydroxide; potassium phenolate; triphenylphosphine; In hexanes; toluene;
DOI:10.1016/j.tet.2011.07.088

Reference yield:

: 18369-65-8
3-acetyloxy-5,5-dimethyl-2-cyclohexenone

: 73183-34-3
bis(pinacol)diborane

: 497959-45-2
1-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-5,5-dimethylcyclohex-1-en-3-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In toluene; at 100 ℃; for 18h; Reagent/catalyst; Catalytic behavior; Sealed tube; Inert atmosphere;
DOI:10.1039/d1nj04008a