18369-65-8

Upstream product

• 108-24-7 acetic anhydride 
• 126-81-8 dimedone 
• 463-51-4 Ketene 
• 3471-13-4 dimedone 
• 64-19-7 acetic acid 
• 495-69-2 Hippuric Acid 
• 122-51-0 orthoformic acid triethyl ester 
• 75-36-5 acetyl chloride 
• 108-22-5 Isopropenyl acetate 
• 104293-02-9 1-ethoxy-2-(trimethylsilyl)vinyl acetate 

Downstream Products

• 90002-62-3 4-bromo-5,5-dimethyl-cyclohexane-1,3-dione 
• 108967-62-0 1-(5,5-dimethyl-3-hydroxy-2-cyclohexen-1-on-2-yl)-2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1755-15-3 2-acetyldimedone 
• 37513-99-8 2-acetyldimedone 
• 88046-55-3 7-ethoxy-4,4-dimethylbicyclo<4.2.0>oct-1(6)-en-2-one 
• 78998-82-0 5,5-dimethyl-3-(phenylseleno)-2-cyclohexen-1-ol 
• 36047-17-3 5,5-dimethyl-3-phenyl-2-cyclohexen-1-one 
• 71835-03-5 1-(1'-naphthalenyl)-5,5-dimethylcyclohex-1-en-3-one 
• 28017-79-0 3-isopropyl-5,5-dimethylcyclohex-2-en-1-one 

Relevant academic research and scientific papers

Synthesis of novel triketone-based acidichromic colorants

This letter presents the synthesis and evaluation of two novel triketone-containing acidichromic colorants. Analysis results indicate that both prepared triketone-containing compounds undergo two distinct and reversible color changes under both strongly acidic and basic conditions. Thus, a pH sensitive triketone functional group is introduced for the first time to design and synthesize acidichromic colorants.

In situ generated acylimidazolium acetate as an efficient catalyst and acylating agent for the acetylation of alcohols, phenols, and amines at ambient temperature

Acylimidazolium acetate was readily prepared in situ from the reaction of imidazole with acetic anhydride and subsequently acted as a catalyst and acylating agent for the efficient acetylation of alcohols, phenols, and amines at ambient temperature.

Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): A structure-activity relationship study

A series of η4-acyloxycyclohexadiene-Fe(CO)3 complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)3 complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by means of a myoglobin assay) and the anti-inflammatory effect of the compounds was assessed by a cellular assay based on the inhibition of NO-production by inducible NO synthase (iNOS). It was demonstrated that the properties (rate of esterase-triggered CO release, iNOS inhibition, cytotoxicity) of the complexes strongly depend on the substitution pattern of the π-ligand and the nature of the acyloxy substituent.

Orthogonal regioselective synthesis of N-alkyl-3-substituted tetrahydroindazolones

A divergent strategy for the regioselective and orthogonal synthesis of complementary regioisomers of N-alkyl-3-substituted-tetrahydroindazolones 3 and 4 was achieved from. Boc-protected alkylhydrazmes 1. The robustness and sub-strate generality of this method were validated by synthesizing 3 and. 4 through the intra- and intermolecular condensation of 1 with various 2-acylcyclohexane-l,3-diones 2 and aldehydes, respectively.

A mild and efficient acetylation of alcohols, phenols and amines with acetic anhydride using La(NO3)3·6H2O as a catalyst under solvent-free conditions

A wide variety of alcohols, phenols and amines are efficiently and selectively converted into the corresponding acetates by treatment with acetic anhydride in the presence of catalytic amounts of La(NO3)3·6H2O under solvent-free conditions at room temperature. The method is compatible with acid sensitive hydroxyl protecting groups such as TBDMS, THP, OBz, OBn, Boc and some isopropylidenes and offers excellent yields of the mono acetates of 1,3-, 1,4- and 1,5-diols.

4,5,6,7-tetrahydroindazole derivatives as antitumor agents

Compounds which are 4,5,6,7-tetrahydroindazole derivative formula (1), wherein the dotted line (x) represents a single or double bond; n is 0 or 1; R1, R2 and R3 have the meanings reported in the description; Ra, R′a, Rb, R′b, Rc, R′c have the meanings reported in the description, also comprising that Ra and Rb together and/or Ra and Rc together form a N-alkylpiperydinyl ring with 1 to 6 carbon atoms in the alkyl chain or a phenyl ring; or pharmaceutically acceptable salts thereof, are useful for treating cell proliferative disorders and Alzheimer's disease.

Photobleaching Activity of 2-(Phenylamino)methylidenecyclohexane-1,3-diones in Tobacco (Nicotiana tabacum) Cultured Cells

A series of phenylalkylidenecyclohexane-1,3-dione derivatives were designed and synthesized as vinylogous analogs of phthalimides, which are known photobleaching herbicides. The bleaching activity of synthesized compounds was assayed with photomixotrophic tobacco cultured cells under either light or dark conditions. Both the chlorophyll and the carotenoid contents of the cells treated with the cyclic diones decreased to almost zero within 24 h under the light condition but not under the dark condition. This rapid emergence of bleaching activity with light is one of the most distinctive actions of Protox-inhibiting herbicides; however, the cyclic dione did not inhibit protoporphyrinogen oxidase in vitro. Thus, we concluded that the cyclic diones possessed a different herbicidal mode of action from Protox-inhibiting herbicide.

-Photocycloaddition of Cyclohexene to 2-Acetyl-5,5-dimethyl-1,3-cyclohexanedione and 3-Acetyl-1,5,5-trimethyl-2,4-pyrrolidinedione

Irradiation of solutions of excess cyclohexene and 2-acetyl-5,5-dimethyl-1,3-cyclohexanedione (1) and 3-acetyl-1,5,5-trimethyl-2,4-pyrrolidinedione (4) results mainly in the formation of 1,5-diones 2 and 5.These originate from intermediate cycloadducts of cyclohexene and the exo-enols of the cyclic 1,3-diketones.The yields decrease with increasing polarity of the solvent.In solution 2 and 5 are in equilibrium with the cyclic hemiacetals 3 and 6.Keywords: -Photocycloaddition; 2-Acetyl-5,5-dimethyl-1,3-cyclohexanedione; 3-Acetyl-1,5,5-trimethyl-2,4-pyrrolidinedione; 2-(2'-Acetyl-cyclohexyl)-5,5-dimethyl-1,3-cyclohexanedione; 3-(2'-Acetyl-cyclohexyl)-1,5,5-trimethyl-2,4-pyrrolidinedione.

3-ACETOXY-2-CYCLOALKEN-1-ONES BY ACETYLATION OF CYCLIC 1,3-DIKETONES WITH KETENE

Acetylation of lower 1,3-cycloalkanediones with ketene takes place exclusively at oxygen in contrast to acyclic β-diketones.Thus, 1,3-cyclopentanedione (I), 1,3-cyclohexanedione (II) and 5,5-dimethyl-1,3-cyclohexanedione (III) afforded the corresponding 3

Investigation of the One-Pot Synthesis of N-(5,6,7,8-Tetrahydro-7,7-dimethyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide

A detailed investigation of the reaction of hippuric acid (2) with dimedone (1) and triethyl orthoformate or other one-carbon sources in acetic anhydride yielding the benzopyran derivatives 3 and many byproducts is described.An explanation of this complex