alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol

Base Information

• Chemical Name: alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol
• CAS No.: 88737-44-4
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• DSSTox Substance ID: DTXSID601008328

Synonyms:BRN 4561370;alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol;1-Piperazineethanol, alpha-(((3-methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-;88737-44-4;DTXSID601008328;LS-112456;1-[(3-methyl-1-benzofuran-4-yl)oxy]-3-(4-phenylpiperazin-1-yl)propan-2-ol

Chemical Property of alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 557.083°C at 760 mmHg
• Flash Point: 290.714°C
• Density: 1.196g/cm³
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 366.19434270
• Heavy Atom Count: 27
• Complexity: 449

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=COC2=C1C(=CC=C2)OCC(CN3CCN(CC3)C4=CC=CC=C4)O

Technology Process of alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol

There total 2 articles about alpha-(((3-Methyl-4-benzofuranyl)oxy)methyl)-4-phenyl-1-piperazineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-phenyl-1-piperazine (92-54-6) + 1-(3-methylbenzofuranyl-4-oxy)-2,3-epoxypropane (30143-52-3) → 1-(3-methylbenzofuranyl-4-oxy)-3-1-(N4-phenyl)piperazinyl>propan-2-ol (88737-44-4)

Guidance literature:

In methanol; for 6h; Heating;

Reference yield:

4-hydroxy-3-methylbenzofuran (3610-15-9) → 1-(3-methylbenzofuranyl-4-oxy)-3-1-(N4-phenyl)piperazinyl>propan-2-ol (88737-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / K₂CO₃ / Heating

2: 74 percent / methanol / 6 h / Heating

With potassium carbonate; In methanol;

upstream raw materials:

4-phenyl-1-piperazine

1-(3-methylbenzofuranyl-4-oxy)-2,3-epoxypropane

4-hydroxy-3-methylbenzofuran

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