4-Ethoxy-3-methoxybenzyl alcohol

Base Information

• Chemical Name: 4-Ethoxy-3-methoxybenzyl alcohol
• CAS No.: 61813-58-9
• Molecular Formula: C10H14 O3
• Molecular Weight: 182.219
• Hs Code.: 2909499000
• European Community (EC) Number: 263-247-5
• DSSTox Substance ID: DTXSID40210808
• Nikkaji Number: J150.026K
• Wikidata: Q72471755
• Mol file: 61813-58-9.mol

Synonyms:4-Ethoxy-3-methoxybenzyl alcohol;61813-58-9;(4-Ethoxy-3-methoxyphenyl)methanol;Benzenemethanol, 4-ethoxy-3-methoxy-;4-Ethoxy-3-methoxybenzylalcohol;EINECS 263-247-5;SCHEMBL579760;3-Methoxy-4-ethoxybenzyl alcohol;DTXSID40210808;CHEBI:194777;MFCD00004656;(4-Ethoxy-3-methoxyphenyl)methanol #;AKOS000247412;AS-81448;4-ETHOXY-3-METHOXY-BENZYL ALCOHOL;CS-0132462;FT-0690436;(4-ETHOXY-3-METHOXY-PHENYL)-METHANOL;EN300-09680;Z56983152

Chemical Property of 4-Ethoxy-3-methoxybenzyl alcohol

Chemical Property:

• Vapor Pressure: 5.51E-05mmHg at 25°C
• Melting Point: 54-59 °C
• Refractive Index: 1.4880 (estimate)
• Boiling Point: 185-187 °C (8 mmHg)
• Flash Point: 131°C
• PSA: 38.69000
• Density: 1.086±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.58620
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxy-3-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)CO)OC

Technology Process of 4-Ethoxy-3-methoxybenzyl alcohol

There total 9 articles about 4-Ethoxy-3-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-ethoxy-3-methoxybenzaldehyde (120-25-2) → (4-ethoxy-3-methoxyphenyl)methanol (61813-58-9)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 4h; chemoselective reaction;

DOI:10.1016/j.tetlet.2015.09.154

Reference yield: 87.0%

ethyl bromide (74-96-4) + 4-hydroxymethyl-2-methoxyphenol (498-00-0) → (4-ethoxy-3-methoxyphenyl)methanol (61813-58-9)

Guidance literature:

With potassium carbonate; caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 15h; Molecular sieve; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.02.017

Reference yield: 76.0%

4-hydroxymethyl-2-methoxyphenol (498-00-0) + ethyl iodide (75-03-6) → (4-ethoxy-3-methoxyphenyl)methanol (61813-58-9)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/ja00291a033

upstream raw materials:

4-ethoxy-3-methoxybenzaldehyde

4-hydroxymethyl-2-methoxyphenol

ethyl iodide

Diazoethan

Downstream raw materials:

1-ethoxy-4-chloromethyl-2-methoxy-benzene

3,4-dimethoxy-benzaldehyde

5,6-dihydro-5E-(methoxycarbonylmethylene)-2-pyrone

4-acetoxymethyl-1-ethoxy-2-methoxy-benzene