1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-

Base Information

Chemical Name:1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-
CAS No.:499121-04-9
Molecular Formula:C31H48O10Si
Molecular Weight:608.802
Hs Code.:

1,7-Dioxaspiro[4.4]nonane-4,6-dione,
2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl-
8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-

Synonyms:

Suppliers and Price of 1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)-

There total 26 articles about 1,7-Dioxaspiro[4.4]nonane-4,6-dione, 2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl- 8-(phenylmethyl)-9-[(triethylsilyl)oxy]-, (5S,8R,9S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 499121-03-8
(3S,4S,5R)-5-Benzyl-3-hydroxy-3-((Z)-(4R,5S)-3-hydroxy-4,5-bis-methoxymethoxy-2-methyl-non-6-enoyl)-4-triethylsilanyloxy-dihydro-furan-2-one

: 499121-04-9
(5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]nonane-4,6-dione

Guidance literature:: With Dess-Martin periodane; In dichloromethane;

Reference yield:

: 499121-00-5
(3S,4S,5R)-5-Benzyl-3-((R)-1-benzyloxy-propyl)-tetrahydro-furan-2,3,4-triol

: 499121-04-9
(5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]nonane-4,6-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1.11 g / N-iodosuccinimide; n-Bu₄NI / CH₂Cl₂ / 72 h / 20 °C

2.1: 95 percent / pyridine / 12 h / 50 °C

3.1: 94 percent / H₂ / Pd/C / ethanol / 72 h

4.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 9 h / 20 °C

5.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 1 h / -78 °C

5.2: tetrahydrofuran; toluene / 1 h / -78 °C

6.1: HF*pyridine; pyridine / 2.5 h / 20 °C

7.1: 23.6 mg / Dess-Martin periodinane / CH₂Cl₂ / 6 h / 20 °C

With pyridine; N-iodo-succinimide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; Dess-Martin periodane; pyridine hydrogenfluoride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; 4.1: Dess-Martin oxidation / 7.1: Dess-Martin oxidation;
DOI:10.1246/bcsj.77.1703

Reference yield:

: 499121-08-3
(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

: 499121-04-9
(5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]nonane-4,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / H₂ / Pd/C / ethanol / 72 h

2.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 9 h / 20 °C

3.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 1 h / -78 °C

3.2: tetrahydrofuran; toluene / 1 h / -78 °C

4.1: HF*pyridine; pyridine / 2.5 h / 20 °C

5.1: 23.6 mg / Dess-Martin periodinane / CH₂Cl₂ / 6 h / 20 °C

With pyridine; hydrogen; potassium hexamethylsilazane; Dess-Martin periodane; pyridine hydrogenfluoride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; 2.1: Dess-Martin oxidation / 5.1: Dess-Martin oxidation;
DOI:10.1246/bcsj.77.1703