499121-08-3

Upstream product

• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 499121-01-6 (2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-dihydroxy-4-butanolide 
• 64638-65-9 5,6-dideoxy-1,2-O-isopropylidene-α-D-erythro-hexofuranos-3-ulose 
• 16749-42-1 5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hexofuranose 
• 100-39-0 benzyl bromide 
• 499120-93-3 (2R,3R,4R,5R)-5-ethyl-4-hydroxy-2,3-isopropylidenedioxy-4-vinyltetrahydrofuran 
• 499120-94-4 (2R,3R,4R)-4-ethyl-2,3-dihydroxy-3-vinyl-4-butanolide 
• 499120-95-5 (2R,3R,4R)-4-ethyl-2,3-isopropylidenedioxy-3-vinyl-4-butanolide 
• 499120-96-6 (2S,3R,4R)-2,3-isopropylidenedioxy-3-vinylhexane-1,4-diol 
• 1054611-03-8 (4R,5S)-4-((R)-1-Benzyloxy-propyl)-2,2-dimethyl-5-trityloxymethyl-4-vinyl-[1,3]dioxolane 
• 499120-98-8 (2R,3S,4R,5R)-5-benzyloxy-3,4-isopropylidenedioxy-1-phenyl-4-vinylheptan-2-ol 
• 499121-00-5 (3S,4S,5R)-5-Benzyl-3-((R)-1-benzyloxy-propyl)-tetrahydro-furan-2,3,4-triol 
• 499120-97-7 (2S,3R,4R)-4-benzyloxy-2,3-isopropylidenedioxy-3-vinyl-hexan-1-ol 
• 499120-92-2 (2R,3R,4R)-4-benzyloxy-2,3-isopropylidenedioxy-3-vinyl-hexanal 

Downstream Products

• 58523-30-1 pseurotin A 
• 149883-42-1 (5S,8S,9R)-8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-8,9-dihydroxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione 
• 499120-90-0 (2S,3S,4R)-4-benzyl-2-propanoyl-2,3-bis(triethylsiloxy)-4-butanolide 
• 499120-89-7 (5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 
• 499121-04-9 (5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-2-hydroxy-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]nonane-4,6-dione 
• 499121-03-8 (3S,4S,5R)-5-Benzyl-3-hydroxy-3-((Z)-(4R,5S)-3-hydroxy-4,5-bis-methoxymethoxy-2-methyl-non-6-enoyl)-4-triethylsilanyloxy-dihydro-furan-2-one 
• 499121-02-7 (3S,4S,5R)-5-Benzyl-3-((Z)-(4R,5S)-3-hydroxy-4,5-bis-methoxymethoxy-2-methyl-non-6-enoyl)-3,4-bis-triethylsilanyloxy-dihydro-furan-2-one 
• 660842-27-3 (5S,8R,9S)-8-benzyl-2-[(1E,3E)-hexa-1,3-dienyl]-9-methoxymethoxy-3-methyl-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 
• 660842-28-4 (5S,8R,9R)-8-benzyl-2-[(1E,3E)-hexa-1,3-dienyl]-8-hydroxy-9-methoxymethoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione 
• 660842-25-1 (5S,8R,9S)-8-benzyl-2-[(1E,3E)-hexa-1,3-dienyl]-3-methyl-9-triethylsiloxy-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 
• 660842-24-0 (2S,3S,4R)-4-benzyl-2-hydroxy-2-[(4E,6E)-3-hydroxy-2-methylnona-4,6-dienoyl]-3-triethylsiloxy-4-butanolide 
• 660842-18-2 (5S,8R,9S)-8-benzyl-2-[(1S,2S,3Z)-1,2-bis(methoxymethoxy)-3-hexenyl]-9-methoxymethoxy-3-methyl-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 
• 499121-09-4 (2R,3S,4R)-4-benzyl-2-[(1R)-1-hydroxypropyl]-2,3-bis(triethylsiloxy)-4-butanolide 

Relevant academic research and scientific papers

Total syntheses of natural pseurotins A, F2, and azaspirene

We describe the total syntheses of natural pseurotins A and F2, inhibitors of chitin synthase, both of which possess an unusual 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione ring system. The total syntheses of these spiro-hetereocyclic natural produ

Stereocontrolled synthesis of a highly functionalized 1,7-dioxaspiro[4.4]Nonane derivative related to antibiotic pseurotins

For a total synthesis of pseurotins, unusual heterospirocyclic antibiotics, a key intermediate (5), having a highly functionalized 1,7-dioxaspiro-[4.4]nonane structure, has been synthesized from diacetone D-glucose.