Isothiazolidine, 2-[[3-bromo-5-(phenylmethyl)phenyl]methyl]-, 1,1-dioxide

Base Information

Chemical Name:Isothiazolidine, 2-[[3-bromo-5-(phenylmethyl)phenyl]methyl]-, 1,1-dioxide
CAS No.:500732-66-1
Molecular Formula:C17H18BrNO2S
Molecular Weight:380.305
Hs Code.:

Synonyms:

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Chemical Property of Isothiazolidine, 2-[[3-bromo-5-(phenylmethyl)phenyl]methyl]-, 1,1-dioxide

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Technology Process of Isothiazolidine, 2-[[3-bromo-5-(phenylmethyl)phenyl]methyl]-, 1,1-dioxide

There total 7 articles about Isothiazolidine, 2-[[3-bromo-5-(phenylmethyl)phenyl]methyl]-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 5908-62-3
isothiazolidine 1,1-dioxide

: 251966-71-9
(3-benzyl-5-bromo)benzyl bromide

: 500732-66-1
2-(3-benzyl-5-bromo-benzyl)-isothiazolidine 1,1-dioxide

Guidance literature:: With potassium carbonate; In acetonitrile; for 36h; Heating;
DOI:10.1021/jm025553u

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 500732-66-1
2-(3-benzyl-5-bromo-benzyl)-isothiazolidine 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / diethyl ether; various solvent(s) / 0.67 h / -78 - -65 °C

1.2: diethyl ether; various solvent(s) / -65 - 20 °C

2.1: 26.4 g / Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / 0 - 20 °C

3.1: n-BuLi / diethyl ether; various solvent(s) / 0.67 h / -78 - -65 °C

3.2: diethyl ether; various solvent(s) / -78 - 20 °C

4.1: 17.0 g / NaBH₄ / methanol / 0 - 20 °C

5.1: 85 percent / CBr₄; PPh₃ / CH₂Cl₂ / 0 - 20 °C

6.1: 99 percent / K₂CO₃ / acetonitrile / 36 h / Heating

With triethylsilane; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; boron trifluoride diethyl etherate; potassium carbonate; triphenylphosphine; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm025553u

Reference yield:

: 71572-36-6
3-benzyl-1,5-dibromobenzene

: 500732-66-1
2-(3-benzyl-5-bromo-benzyl)-isothiazolidine 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; various solvent(s) / 0.67 h / -78 - -65 °C

1.2: diethyl ether; various solvent(s) / -78 - 20 °C

2.1: 17.0 g / NaBH₄ / methanol / 0 - 20 °C

3.1: 85 percent / CBr₄; PPh₃ / CH₂Cl₂ / 0 - 20 °C

4.1: 99 percent / K₂CO₃ / acetonitrile / 36 h / Heating

With sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; potassium carbonate; triphenylphosphine; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm025553u