{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester
CAS No.:1026627-33-7
Molecular Formula:C₃₃H₃₂ClN₃O₅S
Molecular Weight:618.153
Hs Code.:

Synonyms:{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

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Chemical Property of {2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

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Technology Process of {2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

There total 12 articles about {2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89581-84-0
2-chloro-3-(chloromethyl)pyridine

: 1026627-33-7
{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / LiN₃ / dimethylsulfoxide

2.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

3.1: iPr₂NEt / acetonitrile

3.2: acetonitrile

With lithium azide; hydrogen; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm025553u

Reference yield:

: 42330-59-6
(2-chloropyrid-3-yl)methanol

: 1026627-33-7
{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / SOCl₂ / toluene; CH₂Cl₂ / 0 - 20 °C

2.1: 95 percent / LiN₃ / dimethylsulfoxide

3.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

4.1: iPr₂NEt / acetonitrile

4.2: acetonitrile

With thionyl chloride; lithium azide; hydrogen; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm025553u

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 1026627-33-7
{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / diethyl ether; various solvent(s) / 0.67 h / -78 - -65 °C

1.2: diethyl ether; various solvent(s) / -65 - 20 °C

2.1: 26.4 g / Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / 0 - 20 °C

3.1: n-BuLi / diethyl ether; various solvent(s) / 0.67 h / -78 - -65 °C

3.2: diethyl ether; various solvent(s) / -78 - 20 °C

4.1: 17.0 g / NaBH₄ / methanol / 0 - 20 °C

5.1: 85 percent / CBr₄; PPh₃ / CH₂Cl₂ / 0 - 20 °C

6.1: 99 percent / K₂CO₃ / acetonitrile / 36 h / Heating

7.1: Pd(OAc)2; Et₃N; DPPP / Tl(I)OAc / dimethylformamide / 100 °C

8.1: 4.1 g / aq. HCl / tetrahydrofuran / 1 h

9.1: Br₂; AlCl₃ / dioxane

10.1: iPr₂NEt / acetonitrile

10.2: acetonitrile

With hydrogenchloride; triethylsilane; palladium diacetate; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; carbon tetrabromide; boron trifluoride diethyl etherate; 1,3-bis-(diphenylphosphino)propane; bromine; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; thallium(I) acetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 7.1: Heck reaction;
DOI:10.1021/jm025553u