3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester
CAS No.:422550-95-6
Molecular Formula:C₃₆H₃₇N₃O₇S
Molecular Weight:655.772
Hs Code.:

3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

Synonyms:3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

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Chemical Property of 3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

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Technology Process of 3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

There total 14 articles about 3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1026627-33-7
{2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

: 422550-95-6
3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; at 100 ℃; under 12929 Torr;
DOI:10.1021/jm025553u

Reference yield:

: 42330-59-6
(2-chloropyrid-3-yl)methanol

: 422550-95-6
3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / SOCl₂ / toluene; CH₂Cl₂ / 0 - 20 °C

2.1: 95 percent / LiN₃ / dimethylsulfoxide

3.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

4.1: iPr₂NEt / acetonitrile

4.2: acetonitrile

5.1: Et₃N; Pd(PPh₃)2Cl₂ / 100 °C / 12929 Torr

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; lithium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm025553u

Reference yield:

: 89581-84-0
2-chloro-3-(chloromethyl)pyridine

: 422550-95-6
3-[({2-[3-benzyl-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-phenyl]-2-oxo-ethyl}-benzyloxycarbonyl-amino)-methyl]-pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / LiN₃ / dimethylsulfoxide

2.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

3.1: iPr₂NEt / acetonitrile

3.2: acetonitrile

4.1: Et₃N; Pd(PPh₃)2Cl₂ / 100 °C / 12929 Torr

With bis-triphenylphosphine-palladium(II) chloride; lithium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm025553u