2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl ester

Base Information

• Chemical Name: 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl ester
• CAS No.: 500789-41-3
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.276
• Hs Code.: 2934999090
• Mol file: 500789-41-3.mol

Synonyms:4-O-tert-butyl 2-O-methyl morpholine-2,4-dicarboxylate;

Chemical Property of 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl ester

Chemical Property:

• Boiling Point: 313.2±42.0 °C(Predicted)
• PKA: -2.79±0.40(Predicted)
• PSA: 65.07000
• Density: 1.149±0.06 g/cm3(Predicted)
• LogP: 0.73320
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-tert-Butyl2-methylmorpholine-2,4-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl ester

There total 6 articles about 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (189321-66-2) + methyl iodide (74-88-4) → 4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester (500789-41-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 36h;

Reference yield: 96.0%

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (189321-66-2) + diiodomethane (75-11-6) + methyl iodide (74-88-4) → 4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester (500789-41-3)

Guidance literature:

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid; methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

diiodomethane; In tetrahydrofuran; hexane; at 20 ℃; for 48h;

Reference yield: 68.0%

methyl 4-benzylmorpholine-2-carboxylate (135782-29-5) + di-tert-butyl dicarbonate (24424-99-5) → 4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester (500789-41-3)

Guidance literature:

methyl 4-benzylmorpholine-2-carboxylate; With ammonium formate; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; With triethylamine; In acetonitrile; at 0 - 20 ℃; for 2h;

upstream raw materials:

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

methyl iodide

diazomethyl-trimethyl-silane

methyl 4-benzylmorpholine-2-carboxylate

Downstream raw materials:

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate

(RS)-2-(methoxycarbonyl)morpholine

2-{3-[(Z)-hydroxyimino]-3-phenyl-propionyl}-morpholine-4-carboxylic acid tert-butyl ester

2-(3-phenyl-isoxazol-5-yl)-morpholine-4-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "JAK INHIBITOR". Paragraph 0231; 0232; 0233. . Retrieved 2017/12/15.
• 2、 -. "IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY". Page/Page column 175. . Retrieved 2014/02/15.