4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester

Base Information

• Chemical Name: 4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester
• CAS No.: 135782-29-5
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Hs Code.: 2934999090
• Mol file: 135782-29-5.mol

Synonyms:4-benzylmorpholine-2-carboxy ester;

Chemical Property of 4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 314.5±37.0 °C(Predicted)
• PKA: 5?+-.0.10(Predicted)
• PSA: 38.77000
• Density: 1.150
• LogP: 0.99830
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-Benzylmorpholine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Benzylmorpholine-2-carboxylate is used in the preparation of 4-sulfonylmorpholine derivatives as inhibitors of human 11-β-hydroxy steroid dehydrogenase type 1.

Technology Process of 4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester

There total 3 articles about 4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 4-benzylmorpholine-2-carboxylic acid hydrochloride (135072-15-0) → methyl 4-benzylmorpholine-2-carboxylate (135782-29-5)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

Reference yield:

N-Benzylethanolamine (104-63-2) → methyl 4-benzylmorpholine-2-carboxylate (135782-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 12 h / 20 °C

1.2: 0.83 h / -5 °C

2.1: hydrogenchloride / water / 2.5 h / -10 °C / Reflux

3.1: sulfuric acid / 12 h / Reflux

With hydrogenchloride; sulfuric acid; In water; toluene;

Reference yield:

4-benzyl-2-cyanomorpholine (147767-51-9,126645-52-1) → methyl 4-benzylmorpholine-2-carboxylate (135782-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 2.5 h / -10 °C / Reflux

2: sulfuric acid / 12 h / Reflux

With hydrogenchloride; sulfuric acid; In water;

upstream raw materials:

methanol

4-benzylmorpholine-2-carboxylic acid hydrochloride

N-Benzylethanolamine

4-benzyl-2-cyanomorpholine

Downstream raw materials:

4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester

(S)-4-benzyl-morpholine-2-carboxylic acid

(R)-4-benzylmorpholine-2-carboxyester

(R)-4-benzylmorpholine-2-carboxylic acid hydrochloride

Refernces

• 1、 -. "NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE". Page/Page column 57. . Retrieved 2010/11/27.