1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-

Base Information

Chemical Name:1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-
CAS No.:501084-29-3
Molecular Formula:C13H18O4
Molecular Weight:238.284
Hs Code.:
DSSTox Substance ID:DTXSID10449729
Wikidata:Q82269244

Synonyms:1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-;501084-29-3;DTXSID10449729

Suppliers and Price of 1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:238.12050905
Heavy Atom Count:17
Complexity:226

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1COC(OC1CO)C2=CC=C(C=C2)OC
Isomeric SMILES:C[C@@H]1CO[C@@H](O[C@@H]1CO)C2=CC=C(C=C2)OC

Technology Process of 1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)-

There total 5 articles about 1,3-Dioxane-4-methanol, 2-(4-methoxyphenyl)-5-methyl-, (2S,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-Butyl-[(2S,4S,5R)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-ylmethoxy]-diphenyl-silane

: 501084-29-3
(2S,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-ylmethanol

Guidance literature:: With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ja0377596

Reference yield:

: 128329-22-6
(2R,3S)-<(tert-butyldiphenylsilyl)oxy>-2-methyl-1,3-butanediol

: 501084-29-3
(2S,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-ylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: (+)-10-camphorsulphonic acid / 20 °C

2: Et₃N; tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

With tetrabutyl ammonium fluoride; (+)-10-camphorsulfonic acid; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja0377596

Reference yield:

: 2403-58-9
4-methoxybenzaldehyde diethylacetal

: 501084-29-3
(2S,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-ylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: CSA / CH₂Cl₂ / 0.5 h / 40 °C / 11.25 Torr

2: Bu₄NF / tetrahydrofuran / 0.33 h

With tetrabutyl ammonium fluoride; camphor-10-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/1099-0690(200210)2002:20<3455::AID-EJOC3455>3.0.CO;2-V