1,4-Difluoro-2,3-diiodobenzene

Base Information

• Chemical Name: 1,4-Difluoro-2,3-diiodobenzene
• CAS No.: 501432-99-1
• Molecular Formula: C6H2F2I2
• Molecular Weight: 365.888
• DSSTox Substance ID: DTXSID901306909
• Nikkaji Number: J3.456.691G
• Mol file: 501432-99-1.mol

Synonyms:1,4-Difluoro-2,3-diiodobenzene;501432-99-1;1,2-Diiodo-3,6-difluorobenzene;DTXSID901306909;AKOS024263910

Chemical Property of 1,4-Difluoro-2,3-diiodobenzene

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 365.82140
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1F)I)I)F

Technology Process of 1,4-Difluoro-2,3-diiodobenzene

There total 3 articles about 1,4-Difluoro-2,3-diiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,4-difluoro-2-iodobenzene (2265-92-1) → 1,4-difluoro-2,3-diiodobenzene (501432-99-1)

Guidance literature:

With iodine; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃;

DOI:10.1002/1099-0690(200210)2002:19<3351::AID-EJOC3351>3.0.CO;2-I

Reference yield: 44.0%

1,4-difluoro-2-iodo-3-(trimethylsilyl)benzene (1581279-08-4) → 1,4-difluoro-2,3-diiodobenzene (501432-99-1)

Guidance literature:

With Iodine monochloride; In chloroform; for 1h; Reflux; Inert atmosphere;

DOI:10.1021/om401146p

Reference yield:

methanol (67-56-1) + carbon dioxide (124-38-9,18923-20-1) + 1,4-difluoro-2-iodobenzene (2265-92-1) → methyl 2,5-difluorobenzoate + 1,4-difluoro-2,3-diiodobenzene (501432-99-1) + methyl 3,6-difluoro-2-iodobenzoate

Guidance literature:

carbon dioxide; 1,4-difluoro-2-iodobenzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃;

methanol; With boron trifluoride diethyl etherate; at 25 ℃; for 20h;

DOI:10.1002/1099-0690(200210)2002:19<3351::AID-EJOC3351>3.0.CO;2-I

upstream raw materials:

methanol

carbon dioxide

1,4-difluoro-2-iodobenzene

1,4-difluoro-2-iodo-3-(trimethylsilyl)benzene

Downstream raw materials:

1,4-difluoro-2,3-bis(dienthoxyboryl)benzene

2,6-difluoro-3-iodobenzoic acid

1,4-difluoro-2,5-diiodobenzene

methyl 2,6-difluoro-3-iodobenzoate