1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-

Base Information

Chemical Name:1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-
CAS No.:501690-38-6
Molecular Formula:C18H19N3O2
Molecular Weight:309.368
Hs Code.:
DSSTox Substance ID:DTXSID30433185
Nikkaji Number:J3.043.670I
Wikidata:Q82247314

Synonyms:501690-38-6;1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-;DTXSID30433185;1-Butyl-3-amino-4-(3-hydroxyphenyl)-1,2-dihydro-1,8-naphthyridine-2-one

Suppliers and Price of 1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:309.147726857
Heavy Atom Count:23
Complexity:477

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCN1C2=C(C=CC=N2)C(=C(C1=O)N)C3=CC(=CC=C3)O

Technology Process of 1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)-

There total 3 articles about 1,8-Naphthyridin-2(1H)-one, 3-amino-1-butyl-4-(3-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 239099-53-7
1-butyl-3-amino-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine

: 501690-38-6
3-amino-1-butyl-4-(3-hydroxy-phenyl)-1H-[1,8]naphthyridin-2-one

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 1-butyl-4-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridine-3-carbonyl azide

: 501690-38-6
3-amino-1-butyl-4-(3-hydroxy-phenyl)-1H-[1,8]naphthyridin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / dimethylformamide / 3 h / 50 °C

2: 95 percent / BBr₃ / CH₂Cl₂ / 20 °C

With sodium hydroxide; boron tribromide; In dichloromethane; N,N-dimethyl-formamide; 1: Curtius rearrangement;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 185540-07-2
1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid

: 501690-38-6
3-amino-1-butyl-4-(3-hydroxy-phenyl)-1H-[1,8]naphthyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: diphenylphosphoryl azide; Et₃N / dimethylformamide / 2 h / 50 °C

2: aq. NaOH / dimethylformamide / 3 h / 50 °C

3: 95 percent / BBr₃ / CH₂Cl₂ / 20 °C

With sodium hydroxide; diphenylphosphoranyl azide; boron tribromide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2: Curtius rearrangement;
DOI:10.1016/j.bmcl.2005.09.056