4-Iso-propoxyphenylboronic acid pinacol ester

Base Information

• Chemical Name: 4-Iso-propoxyphenylboronic acid pinacol ester
• CAS No.: 502649-34-5
• Molecular Formula: C15H23BO3
• Molecular Weight: 0.00000
• Mol file: 502649-34-5.mol

Synonyms:

Chemical Property of 4-Iso-propoxyphenylboronic acid pinacol ester

Chemical Property:

• Boiling Point: 347.2±25.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

4-Iso-propoxyphenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Iso-propoxyphenylboronic acid pinacol ester

There total 2 articles about 4-Iso-propoxyphenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-bromo-4-isopropoxybenzene (6967-88-0) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-(4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (502649-34-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In 1,4-dioxane; at 90 ℃; for 42h;

Reference yield:

isopropoxybenzene (2741-16-4) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-(4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (502649-34-5) + C15H23BO3 + C21H34B2O5

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 2’,7’-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4,5-diaza-9,9’-spirobifluorene; In 1,4-dioxane; at 90 ℃; for 16h; regioselective reaction;

DOI:10.1126/science.abm7599

Reference yield: 82.5%

5,6-dibromopyridin-2-ylamine (89284-11-7) + 2-(4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (502649-34-5) → 5-bromo-6-(4-isopropoxyphenyl)pyridin-2-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; toluene; at 85 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00586

upstream raw materials:

1-bromo-4-isopropoxybenzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

isopropoxybenzene

Refernces

• 1、 -. "PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS". . . Retrieved 2008/06/13.