6967-88-0

Basic information

• Product Name: 1-bromo-4-propan-2-yloxy-benzene
• Synonyms: 1-bromo-4-propan-2-yloxy-benzene;Nsc20697;1-Bromo-4-isopropoxylbenzene;4-bromophenyl isopropyl ether
• CAS NO: 6967-88-0
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.1
• Mol File: 6967-88-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 239.2°C at 760 mmHg
• Flash Point: 106.6°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 0.0628mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 1-bromo-4-propan-2-yloxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-propan-2-yloxy-benzene(6967-88-0)
• EPA Substance Registry System: 1-bromo-4-propan-2-yloxy-benzene(6967-88-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6967-88-0(Hazardous Substances Data)

Usage

General Description

1-bromo-4-propan-2-yloxy-benzene, also known as p-bromo-α-(propoxy)benzene, is a chemical compound with the molecular formula C9H11BrO. It is a pale yellow liquid with a molecular weight of 213.08 g/mol. 1-bromo-4-propan-2-yloxy-benzene is used in organic synthesis as a building block for various pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as an intermediate in the production of dyes, pigments, and other industrial chemicals. Additionally, it has applications in the field of materials science and polymer chemistry for the production of polymers and other advanced materials. However, it is important to handle this compound with care, as it is a hazardous substance and should be used in a well-ventilated area and with appropriate protective equipment.

InChI:InChI=1/C9H11BrO/c1-7(2)11-9-5-3-8(10)4-6-9/h3-7H,1-2H3

Upstream product

• 75-30-9 2-iodo-propane 
• 106-41-2 4-bromo-phenol 
• 187737-37-7 propene 
• 2741-16-4 isopropoxybenzene 
• 75-26-3 isopropyl bromide 
• 139-02-6 sodium phenoxide 
• 67-63-0 isopropyl alcohol 
• 1237512-14-9 trimethyl((3-methyl-2-phenylbut-2-yl)peroxy)silane 

Downstream Products

• 902169-36-2 5-benzyloxy-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester 
• 902757-12-4 6-benzyloxy-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester 
• 153624-46-5 4-(isopropoxy)phenylboronic acid 
• 1244044-77-6 1,4-bis[2,2-bis(4-i-propoxyphenyl)vinyl]benzene 
• 1069043-42-0 methyl 3-[1-(4-isopropoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate 
• 28530-36-1 1-isopropoxy-4-isopropylbenzene 
• 1594130-88-7 C₂₆H₃₆N₂O₄ 

Relevant articles and documents

Synthesis of Vitisins A and D Enabled by a Persistent Radical Equilibrium

The first total synthesis of the resveratrol tetramers vitisin A and vitisin D is reported. Electrochemical generation and selective dimerization of persistent radicals is followed by thermal isomerization of the symmetric C8b-C8c dimer to the C3c-C8b isomer, providing rapid entry into the vitisin core. Computational results suggest that this synthetic approach mimics Nature's strategy for constructing these complex molecules. Sequential acid-mediated rearrangements consistent with the proposed biogenesis of these compounds afford vitisin A and vitisin D. The rapid synthesis of these complex molecules will enable further study of their pharmacological potential.

Cu-Catalyzed: O -alkylation of phenol derivatives with alkylsilyl peroxides

A Cu-catalyzed O-alkylation of phenol derivatives using alkylsilyl peroxides as alkyl radical precursors is described. The reaction proceeds smoothly under mild reaction conditions and the use of two different ligands with a Cu catalyst provides a wide range of products. A mechanistic study suggested that the reaction proceeds via a radical mechanism. This journal is

Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

Halogenated aromatic compounds are the cores of many pharmaceutical, agricultural and chemical products but they are commonly prepared using electrophilic halogenation reactions in non-green chlorinated solvents under harsh conditions. A separate problem happens in the aromatic halogenation of thioarenes because they readily undergo oxidative side-reactions. Herein we report an environmentally benign electrophilic bromination of aromatics using an indole-catalytic protocol, which is suitable for a wide range of substrates including thioarenes.